Growth before 2 years of age and serum lipids 60 years later: the Helsinki Birth Cohort study
Growth before 2 years of age and serum lipids 60 years later: the Helsinki Birth Cohort study
Background: small body size at birth and slow growth during the first 2 years after birth, leading to low body mass index (BMI) at 2 years, are associated with coronary heart disease and stroke in adult life. We tested the hypothesis that this path of growth is associated with an atherogenic lipid profile in later life.
Methods: we measured serum lipid concentrations at age 57-70 years in 1999 members of the Helsinki Birth Cohort. They were randomly selected from an original cohort of 8760 people and had on average 11 measurements of height and weight between birth and 2 years of age.
Results: the 18% of subjects who used lipid-lowering medication had a lower BMI at birth and at 2 years. These subjects were excluded from the analyses of lipid profiles. A 1 kg/m(2) lower BMI at birth was associated with 0.051 mmol/l (95% CI -0.001 to 0.103; P = 0.05) higher non-HDL cholesterol and 0.018 g/l higher (0.005-0.031; P = 0.006) apolipoprotein B concentrations. A slower increase in BMI during the first 6 months after birth was associated with lower HDL and higher non-HDL cholesterol concentrations. A 1 kg/m(2) lower BMI at 2 years was associated with 0.020 mmol/l lower (0.004-0.036; P = 0.02) HDL cholesterol and 0.059 mmol/l (0.020-0.099; P = 0.003) higher non-HDL cholesterol and 0.018 mmol/l higher (0.008-0.028; P < 0.001) apolipoprotein B concentrations. The age at weaning off breast milk was not associated with lipid profile in later life.
Conclusion: small body size at birth and slow weight gain during infancy are associated with an atherogenic lipid profile in adult life
size, hypothesis, cholesterol, coronary heart disease, research, height, body mass index, growth, weight, disease, heart, weight gain, milk, lipids, cardiovascular disease, adult, later life, body size, mass, birth, methods, cohort, weaning, cohort studies, stroke
280-289
Kajantie, Eero
d68d55b6-6df1-4195-a914-44c738a6db93
Barker, David J.P.
5c773838-b094-4ac1-999b-b5869717f243
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Forsen, Tom
77245dbe-fc1f-4e6f-a2bb-6f1a77918cd2
Eriksson, Johan G.
eb96b1c5-af07-4a52-8a73-7541451d32cd
2008
Kajantie, Eero
d68d55b6-6df1-4195-a914-44c738a6db93
Barker, David J.P.
5c773838-b094-4ac1-999b-b5869717f243
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Forsen, Tom
77245dbe-fc1f-4e6f-a2bb-6f1a77918cd2
Eriksson, Johan G.
eb96b1c5-af07-4a52-8a73-7541451d32cd
Kajantie, Eero, Barker, David J.P., Osmond, Clive, Forsen, Tom and Eriksson, Johan G.
(2008)
Growth before 2 years of age and serum lipids 60 years later: the Helsinki Birth Cohort study.
International Journal of Epidemiology, 37 (2), .
(doi:10.1093/ije/dyn012).
Abstract
Background: small body size at birth and slow growth during the first 2 years after birth, leading to low body mass index (BMI) at 2 years, are associated with coronary heart disease and stroke in adult life. We tested the hypothesis that this path of growth is associated with an atherogenic lipid profile in later life.
Methods: we measured serum lipid concentrations at age 57-70 years in 1999 members of the Helsinki Birth Cohort. They were randomly selected from an original cohort of 8760 people and had on average 11 measurements of height and weight between birth and 2 years of age.
Results: the 18% of subjects who used lipid-lowering medication had a lower BMI at birth and at 2 years. These subjects were excluded from the analyses of lipid profiles. A 1 kg/m(2) lower BMI at birth was associated with 0.051 mmol/l (95% CI -0.001 to 0.103; P = 0.05) higher non-HDL cholesterol and 0.018 g/l higher (0.005-0.031; P = 0.006) apolipoprotein B concentrations. A slower increase in BMI during the first 6 months after birth was associated with lower HDL and higher non-HDL cholesterol concentrations. A 1 kg/m(2) lower BMI at 2 years was associated with 0.020 mmol/l lower (0.004-0.036; P = 0.02) HDL cholesterol and 0.059 mmol/l (0.020-0.099; P = 0.003) higher non-HDL cholesterol and 0.018 mmol/l higher (0.008-0.028; P < 0.001) apolipoprotein B concentrations. The age at weaning off breast milk was not associated with lipid profile in later life.
Conclusion: small body size at birth and slow weight gain during infancy are associated with an atherogenic lipid profile in adult life
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Published date: 2008
Keywords:
size, hypothesis, cholesterol, coronary heart disease, research, height, body mass index, growth, weight, disease, heart, weight gain, milk, lipids, cardiovascular disease, adult, later life, body size, mass, birth, methods, cohort, weaning, cohort studies, stroke
Identifiers
Local EPrints ID: 61264
URI: http://eprints.soton.ac.uk/id/eprint/61264
ISSN: 0300-5771
PURE UUID: ce33d3b7-b75b-4644-82e4-e7a01d1e0fda
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Date deposited: 08 Sep 2008
Last modified: 16 Mar 2024 02:50
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Contributors
Author:
Eero Kajantie
Author:
David J.P. Barker
Author:
Tom Forsen
Author:
Johan G. Eriksson
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