The University of Southampton
University of Southampton Institutional Repository

The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women

Record type: Article

SUMMARY: BMD and clinical risk factors predict hip and other osteoporotic fractures. The combination of clinical risk factors and BMD provide higher specificity and sensitivity than either alone.
INTRODUCTION AND HYPOTHESES: To develop a risk assessment tool based on clinical risk factors (CRFs) with and without BMD.
METHODS: Nine population-based studies were studied in which BMD and CRFs were documented at baseline. Poisson regression models were developed for hip fracture and other osteoporotic fractures, with and without hip BMD. Fracture risk was expressed as gradient of risk (GR, risk ratio/SD change in risk score).
RESULTS: CRFs alone predicted hip fracture with a GR of 2.1/SD at the age of 50 years and decreased with age. The use of BMD alone provided a higher GR (3.7/SD), and was improved further with the combined use of CRFs and BMD (4.2/SD). For other osteoporotic fractures, the GRs were lower than for hip fracture. The GR with CRFs alone was 1.4/SD at the age of 50 years, similar to that provided by BMD (GR = 1.4/SD) and was not markedly increased by the combination (GR = 1.4/SD). The performance characteristics of clinical risk factors with and without BMD were validated in eleven independent population-based cohorts.
CONCLUSIONS: The models developed provide the basis for the integrated use of validated clinical risk factors in men and women to aid in fracture risk prediction.

Full text not available from this repository.

Citation

Kanis, J.A., Oden, A., Johnell, O., Johansson, H., De Laet, C., Brown, J., Burckhardt, P., Cooper, C., Christiansen, C., Cummings, S., Eisman, J.A., Fujiwara, S., Gluer, C., Goltzman, D., Hans, D., Krieg, M.A., La Croix, A., McCloskey, E., Mellstrom, D., Melton, L.J., III Pols, H., Reeve, J., Sanders, K., Schott, A.M., Silman, A., Torgerson, D., Van Staa, T., Watts, N.B. and Yoshimura, N. (2007) The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women Osteoporosis International, 18, (8), pp. 1033-1046. (doi:10.1007/s00198-007-0343-y).

More information

Published date: 2007
Keywords: cohort, research, methods, risk, risk factors, disease, risk assessment, fractures, hip, women, bone

Identifiers

Local EPrints ID: 61275
URI: http://eprints.soton.ac.uk/id/eprint/61275
ISSN: 0937-941X
PURE UUID: 3e933cd7-214c-4353-9c7c-7e3018b57eb5

Catalogue record

Date deposited: 09 Sep 2008
Last modified: 17 Jul 2017 14:22

Export record

Altmetrics

Contributors

Author: J.A. Kanis
Author: A. Oden
Author: O. Johnell
Author: H. Johansson
Author: C. De Laet
Author: J. Brown
Author: P. Burckhardt
Author: C. Cooper
Author: C. Christiansen
Author: S. Cummings
Author: J.A. Eisman
Author: S. Fujiwara
Author: C. Gluer
Author: D. Goltzman
Author: D. Hans
Author: M.A. Krieg
Author: A. La Croix
Author: E. McCloskey
Author: D. Mellstrom
Author: L.J. Melton
Author: H. III Pols
Author: J. Reeve
Author: K. Sanders
Author: A.M. Schott
Author: A. Silman
Author: D. Torgerson
Author: T. Van Staa
Author: N.B. Watts
Author: N. Yoshimura

University divisions


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×