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Longitudinal reference ranges for ductus venosus flow velocities and waveform indices

Kessler, J., Rasmussen, S., Hanson, M. and Kiserud, T. (2006) Longitudinal reference ranges for ductus venosus flow velocities and waveform indices Ultrasound in Obstetrics and Gynecology, 28, (7), pp. 890-898. (doi:10.1002/uog.3857).

Record type: Article


OBJECTIVES: Serial Doppler measurements of the ductus venosus are used increasingly for monitoring fetuses at risk of hemodynamic compromise, but existing reference ranges are based on cross-sectional studies and thus are less suitable for comparison with serial measurements. We aimed to establish longitudinal reference ranges for ductus venosus flow velocities and waveform indices and to provide the necessary terms for calculating conditional reference ranges for serial measurements. METHODS: This was a longitudinal study of 160 low-risk pregnancies. Pulsed Doppler ultrasound was used to record ductus venosus blood flow velocities at 4-week intervals from 20-22 weeks of gestation onwards. RESULTS: With a success rate of 93%, 547 measurements (four or five in each fetus) were used to establish reference ranges. The time-averaged maximum velocity was 50 cm/s at 21 weeks of gestation, increased to 60 cm/s at 32 weeks, and remained so until term. Similarly, the peak systolic velocity increased from 59 cm/s at 21 weeks to 71 cm/s at 31 weeks and remained so until term. The end-diastolic velocity showed a continuous increase from 31 cm/s at 21 weeks to 43 cm/s at 40 weeks. The pulsatility index for veins decreased from 0.57 at 21 weeks to 0.44 at 40 weeks. When conditioned by a previous measurement, the reference ranges for the next observation became narrower and commonly shifted compared with those of the entire population. CONCLUSION: The new longitudinal reference ranges presented here reflect the development of the ductus venosus flow velocities and velocity indices and are thus appropriate for serial measurements, particularly if conditional terms are included

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Published date: November 2006
Keywords: blood flow, Doppler, ductus venosus, fetus, reference interval, ultrasound


Local EPrints ID: 61285
ISSN: 0960-7692
PURE UUID: f6755108-b7b1-4bec-8770-719df245ebc3

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Date deposited: 08 Sep 2008
Last modified: 17 Jul 2017 14:22

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Author: J. Kessler
Author: S. Rasmussen
Author: M. Hanson
Author: T. Kiserud

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