Interactions between microvascular and macrovascular disease in diabetes: pathophysiology and therapeutic implications
Interactions between microvascular and macrovascular disease in diabetes: pathophysiology and therapeutic implications
Convention partitions the complications of diabetes into two main subtypes. First are the diabetes-specific microvascular complications of retinopathy, nephropathy and neuropathy; second are the atherothrombotic macrovascular complications that account for the majority of premature deaths. Pathological interactions between microvascular and macrovascular complications, for example, nephropathy and macrovascular disease, are common. Similar mechanisms and shared risk factors drive the development and progression of both small and large vessel disease. This concept has therapeutic implications. Mounting evidence points to the need for multifactorial strategies to prevent vascular complications in subjects with diabetes and/or the metabolic syndrome. We advocate a combined therapeutic approach that addresses small and large vessel disease. Preferential use should be made of drug regimens that (i) maximize vascular protection, (ii) reduce the risk of iatrogenic vascular damage and (iii) minimize the increasing problem of polypharmacy
male, obesity, complications, metabolic syndrome, humans, disease, diabetic nephropathies, hypertension, review, pharmacology, diabetes mellitus, risk, type 2, syndrome, diabetic retinopathy, therapy, female, insulin, therapeutic use, risk factors, etiology, diabetic angiopathies, diabetes, atherosclerosis
781-791
Krentz, A.J.
9f3c00da-2737-4e5f-9403-e803af2744f6
Clough, G.
9f19639e-a929-4976-ac35-259f9011c494
Byrne, C.D.
1370b997-cead-4229-83a7-53301ed2a43c
2007
Krentz, A.J.
9f3c00da-2737-4e5f-9403-e803af2744f6
Clough, G.
9f19639e-a929-4976-ac35-259f9011c494
Byrne, C.D.
1370b997-cead-4229-83a7-53301ed2a43c
Krentz, A.J., Clough, G. and Byrne, C.D.
(2007)
Interactions between microvascular and macrovascular disease in diabetes: pathophysiology and therapeutic implications.
Diabetes, Obesity and Metabolism, 9 (6), .
Abstract
Convention partitions the complications of diabetes into two main subtypes. First are the diabetes-specific microvascular complications of retinopathy, nephropathy and neuropathy; second are the atherothrombotic macrovascular complications that account for the majority of premature deaths. Pathological interactions between microvascular and macrovascular complications, for example, nephropathy and macrovascular disease, are common. Similar mechanisms and shared risk factors drive the development and progression of both small and large vessel disease. This concept has therapeutic implications. Mounting evidence points to the need for multifactorial strategies to prevent vascular complications in subjects with diabetes and/or the metabolic syndrome. We advocate a combined therapeutic approach that addresses small and large vessel disease. Preferential use should be made of drug regimens that (i) maximize vascular protection, (ii) reduce the risk of iatrogenic vascular damage and (iii) minimize the increasing problem of polypharmacy
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Published date: 2007
Keywords:
male, obesity, complications, metabolic syndrome, humans, disease, diabetic nephropathies, hypertension, review, pharmacology, diabetes mellitus, risk, type 2, syndrome, diabetic retinopathy, therapy, female, insulin, therapeutic use, risk factors, etiology, diabetic angiopathies, diabetes, atherosclerosis
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Local EPrints ID: 61301
URI: http://eprints.soton.ac.uk/id/eprint/61301
ISSN: 1462-8902
PURE UUID: add136b5-c790-4d13-b97b-3e4d2f9885d1
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Date deposited: 10 Sep 2008
Last modified: 23 Jul 2022 01:45
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Author:
A.J. Krentz
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