Intrauterine programming of bone. Part 1: alteration of the osteogenic environment

Lanham, S.A., Roberts, C., Cooper, C. and Oreffo, R.O. (2007) Intrauterine programming of bone. Part 1: alteration of the osteogenic environment Osteoporosis International, 19, (2), pp. 147-156. (doi:10.1007/s00198-007-0443-8).


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Osteoporosis is believed to partly be programmed in utero. Rat dams were given a low protein diet during pregnancy and 135 offspring studied at different ages. Bone biochemistry showed altered characteristics. Altered in utero diet has consequences for later life.

Introduction: Epidemiological studies suggest skeletal growth is programmed during intrauterine and early postnatal life. We have investigated this in a rat model of maternal protein insufficiency.

Methods: Dams received either 18% w/w (control) or 9% w/w (low protein) diet during pregnancy, and the offspring were studied at selected time points (4, 8, 12, 16, 20, 47 weeks).

Results: Alkaline phosphatase activity in controls reached peak levels from 8 to 20 weeks of age. In contrast, restricted diet offspring were at peak levels from 4 weeks of age. Peak levels were similar in both groups. Serum IGF-1 levels were lower in female restricted diet offspring at 4 weeks of age, and serum osteocalcin was significantly higher at 4 weeks of age in male and female offspring from mothers fed the restricted diet, whereas serum 25-OH vitamin D was significantly lower in restricted diet males at 8, 12, and 20 weeks of age.

Conclusions: These data indicate that a low protein diet in utero affected the osteogenic environment in the offspring with effects that persist into late adulthood. These results indicate the key role of the nutritional environment in early development on programming of skeletal development with implicit consequences in later life.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1007/s00198-007-0443-8
ISSNs: 0937-941X (print)
Keywords: mothers, later life, pregnancy, growth, bone, protein, disease, vitamin d, female, development, diet, maternal, activity, research, developmental origins, in-utero, male, osteocalcin, time, alkaline phosphatase, consequences, osteoporosis, rat, methods, health, origins, environment, programming
Subjects: Q Science > QP Physiology
ePrint ID: 61319
Date :
Date Event
2007e-pub ahead of print
February 2008Published
Date Deposited: 09 Sep 2008
Last Modified: 16 Apr 2017 17:31
Further Information:Google Scholar

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