The University of Southampton
University of Southampton Institutional Repository

Intrauterine programming of bone. Part 1: alteration of the osteogenic environment

Lanham, S.A., Roberts, C., Cooper, C. and Oreffo, R.O. (2008) Intrauterine programming of bone. Part 1: alteration of the osteogenic environment Osteoporosis International, 19, (2), pp. 147-156. (doi:10.1007/s00198-007-0443-8).

Record type: Article


Osteoporosis is believed to partly be programmed in utero. Rat dams were given a low protein diet during pregnancy and 135 offspring studied at different ages. Bone biochemistry showed altered characteristics. Altered in utero diet has consequences for later life.

Introduction: Epidemiological studies suggest skeletal growth is programmed during intrauterine and early postnatal life. We have investigated this in a rat model of maternal protein insufficiency.

Methods: Dams received either 18% w/w (control) or 9% w/w (low protein) diet during pregnancy, and the offspring were studied at selected time points (4, 8, 12, 16, 20, 47 weeks).

Results: Alkaline phosphatase activity in controls reached peak levels from 8 to 20 weeks of age. In contrast, restricted diet offspring were at peak levels from 4 weeks of age. Peak levels were similar in both groups. Serum IGF-1 levels were lower in female restricted diet offspring at 4 weeks of age, and serum osteocalcin was significantly higher at 4 weeks of age in male and female offspring from mothers fed the restricted diet, whereas serum 25-OH vitamin D was significantly lower in restricted diet males at 8, 12, and 20 weeks of age.

Conclusions: These data indicate that a low protein diet in utero affected the osteogenic environment in the offspring with effects that persist into late adulthood. These results indicate the key role of the nutritional environment in early development on programming of skeletal development with implicit consequences in later life.

Full text not available from this repository.

More information

e-pub ahead of print date: 2007
Published date: February 2008
Keywords: mothers, later life, pregnancy, growth, bone, protein, disease, vitamin d, female, development, diet, maternal, activity, research, developmental origins, in-utero, male, osteocalcin, time, alkaline phosphatase, consequences, osteoporosis, rat, methods, health, origins, environment, programming


Local EPrints ID: 61319
ISSN: 0937-941X
PURE UUID: 5dab4972-65ed-4776-b059-f8a192cb3b4d
ORCID for S.A. Lanham: ORCID iD
ORCID for C. Cooper: ORCID iD
ORCID for R.O. Oreffo: ORCID iD

Catalogue record

Date deposited: 09 Sep 2008
Last modified: 17 Jul 2017 14:22

Export record



Author: S.A. Lanham ORCID iD
Author: C. Roberts
Author: C. Cooper ORCID iD
Author: R.O. Oreffo ORCID iD

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.