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Geographical variation in relationships between parental body size and offspring phenotype at birth

Leary, Sam, Fall, Caroline, Osmond, Clive, Lovel, Hermione, Campbell, Doris, Eriksson, Johan, Forrester, Terrence, Godfrey, Keith, Hill, Jacqui, Jie, Mi, Law, Catherine, Newby, Rachel, Robinson, Sian and Yajnik, Chittaranjan (2006) Geographical variation in relationships between parental body size and offspring phenotype at birth Acta Obstetricia et Gynecologica Scandinavica, 85, (9), pp. 1066-1079.

Record type: Article

Abstract

BACKGROUND: Size and body proportions at birth are partly determined by maternal body composition, but most studies of mother-baby relationships have only considered the effects of maternal height and weight on offspring birth weight, and few have examined the size of effects. Paternal size and body composition also play a role, primarily through the fetal genome, although few studies have investigated relationships with neonatal phenotype. METHODS: Data from the UK, Finland, India, Sri Lanka, China, DR Congo, Nigeria and Jamaica were used to investigate the effects of maternal measures (derived at 30 weeks' gestation, n=16,418), and also paternal size (n=3,733) on neonatal phenotype, for singleton, live-born, term births. RESULTS: After accounting for variation in maternal size and shape across populations, differences in neonatal phenotype were markedly reduced. Mother-baby relationships were similar across populations, although some were stronger in developing countries. Maternal height was generally the strongest predictor of neonatal length, maternal head circumference of neonatal head and maternal skinfold thickness of neonatal skinfolds. Relationships with maternal arm muscle area were generally weak. Effects of paternal height and body mass index were weaker than the equivalent maternal measurements in most studies. CONCLUSIONS: Differences in maternal body composition account for a large part of the geographical variation in neonatal phenotype. The size of the effects of all maternal measures on neonatal phenotype suggests that nutrition at every stage of the mother's life cycle may influence fetal growth. Further research is needed into father-baby relationships and the genetic mechanisms that influence fetal growth.

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Published date: September 2006

Identifiers

Local EPrints ID: 61324
URI: http://eprints.soton.ac.uk/id/eprint/61324
ISSN: 0001-6349
PURE UUID: 8c1edc6d-3088-49c4-a84f-4c036cce543e
ORCID for Clive Osmond: ORCID iD orcid.org/0000-0002-9054-4655
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618
ORCID for Sian Robinson: ORCID iD orcid.org/0000-0003-1766-7269

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Date deposited: 15 Oct 2008
Last modified: 24 Aug 2017 01:57

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Contributors

Author: Sam Leary
Author: Caroline Fall
Author: Clive Osmond ORCID iD
Author: Hermione Lovel
Author: Doris Campbell
Author: Johan Eriksson
Author: Terrence Forrester
Author: Keith Godfrey ORCID iD
Author: Jacqui Hill
Author: Mi Jie
Author: Catherine Law
Author: Rachel Newby
Author: Sian Robinson ORCID iD
Author: Chittaranjan Yajnik

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