Fish oil induced increase in walking distance, but not ankle brachial pressure index, in peripheral arterial disease is dependent on both body mass index and inflammatory genotype
Fish oil induced increase in walking distance, but not ankle brachial pressure index, in peripheral arterial disease is dependent on both body mass index and inflammatory genotype
Peripheral arterial disease (PAD) is an atherosclerotic disease. Evidence suggests that atherosclerosis is an inflammatory condition and long chain n-3 fatty acids, found in oily fish and fish oils, have been shown to reduce inflammation. Genetic and lifestyle factors such as body mass index (BMI) also influence inflammation. In this study we have examined the effect of fish oil in patients with claudication secondary to PAD. Fish oil supplementation, providing 1g EPA and 0.7 g DHA per day for 12 weeks, increased walking distance on a treadmill set at 3.2 km/h with a 7% incline. Walking distance to first pain increased from 76.2+/-8.5 m before fish oil to 140.6+/-25.5 m after fish oil (mean+/-SEM, p=0.004) and total distance walked increased from 160.0+/-21.5 m before fish oil to 242.1+/-34.5 m after fish oil (p=0.002). Fish oil supplementation also improved ankle brachial pressure index (ABPI) from 0.599+/-0.017 before fish oil to 0.776+/-0.030 after fish oil (p<0.001). The increase in walking distance was dependent on both BMI and genotype for single nucleotide polymorphisms in the genes encoding the pro-inflammatory cytokines tumour necrosis factor-alpha and interleukin (IL)-1beta and the anti-inflammatory cytokine IL-10 (detected using amplification refractory mutation system polymerase chain reaction). Neither BMI nor any of the genotypes examined affected the ability of fish oil to increase ABPI. The mechanisms by which fish oil affects walking distance and ABPI do not appear to be the same.
331-340
Madden, Jacqueline
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Brunner, Andreas
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Dastur, Neville D.
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Tan, Rebecca M.
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Nash, Gerard B.
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Rainger, G. Ed
f437d109-e403-40a4-895a-21f740503a86
Shearman, Cliff P.
cf4d6317-f54d-4ab3-ba49-c6797897bbcf
Calder, Philip C.
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Grimble, Robert F.
3100e4d2-8f29-4ca6-a95d-38a6a764865f
June 2007
Madden, Jacqueline
0771e352-d432-41ea-8a7e-4704c1efca46
Brunner, Andreas
0d6b87b9-3a36-4198-84bf-e2e4bfc39c03
Dastur, Neville D.
829f6a81-a6c2-4446-a95c-fea851586650
Tan, Rebecca M.
64cabfea-9b79-46f2-874e-98fa0a65700f
Nash, Gerard B.
2a1bc801-f2bf-47ba-be93-e259f47fe9c5
Rainger, G. Ed
f437d109-e403-40a4-895a-21f740503a86
Shearman, Cliff P.
cf4d6317-f54d-4ab3-ba49-c6797897bbcf
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Grimble, Robert F.
3100e4d2-8f29-4ca6-a95d-38a6a764865f
Madden, Jacqueline, Brunner, Andreas, Dastur, Neville D., Tan, Rebecca M., Nash, Gerard B., Rainger, G. Ed, Shearman, Cliff P., Calder, Philip C. and Grimble, Robert F.
(2007)
Fish oil induced increase in walking distance, but not ankle brachial pressure index, in peripheral arterial disease is dependent on both body mass index and inflammatory genotype.
Prostaglandins, Leukotrienes and Essential Fatty Acids, 76 (6), .
(doi:10.1016/j.plefa.2007.04.003).
Abstract
Peripheral arterial disease (PAD) is an atherosclerotic disease. Evidence suggests that atherosclerosis is an inflammatory condition and long chain n-3 fatty acids, found in oily fish and fish oils, have been shown to reduce inflammation. Genetic and lifestyle factors such as body mass index (BMI) also influence inflammation. In this study we have examined the effect of fish oil in patients with claudication secondary to PAD. Fish oil supplementation, providing 1g EPA and 0.7 g DHA per day for 12 weeks, increased walking distance on a treadmill set at 3.2 km/h with a 7% incline. Walking distance to first pain increased from 76.2+/-8.5 m before fish oil to 140.6+/-25.5 m after fish oil (mean+/-SEM, p=0.004) and total distance walked increased from 160.0+/-21.5 m before fish oil to 242.1+/-34.5 m after fish oil (p=0.002). Fish oil supplementation also improved ankle brachial pressure index (ABPI) from 0.599+/-0.017 before fish oil to 0.776+/-0.030 after fish oil (p<0.001). The increase in walking distance was dependent on both BMI and genotype for single nucleotide polymorphisms in the genes encoding the pro-inflammatory cytokines tumour necrosis factor-alpha and interleukin (IL)-1beta and the anti-inflammatory cytokine IL-10 (detected using amplification refractory mutation system polymerase chain reaction). Neither BMI nor any of the genotypes examined affected the ability of fish oil to increase ABPI. The mechanisms by which fish oil affects walking distance and ABPI do not appear to be the same.
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Published date: June 2007
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WEB/URL: --> PM:17600695;
; AU: --> Madden, J., Brunner, A., Dastur, N. D., Tan, R. M., Nash, G. B., Rainger, G. E., Shearman, C. P., Calder, P. C., and Grimble, R. F.; note --> Volume => 76;
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Local EPrints ID: 61352
URI: http://eprints.soton.ac.uk/id/eprint/61352
PURE UUID: f9d76c48-6d69-43a3-bfe9-4df272c1f9e3
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Date deposited: 30 Sep 2008
Last modified: 16 Mar 2024 02:51
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Author:
Jacqueline Madden
Author:
Andreas Brunner
Author:
Neville D. Dastur
Author:
Rebecca M. Tan
Author:
Gerard B. Nash
Author:
G. Ed Rainger
Author:
Robert F. Grimble
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