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The benefits of oestrogens on postprandial lipid metabolism are lost in post-menopausal women with Type 2 diabetes

Masding, M.G., Stears, A.J., Burdge, G.C., Wootton, S.A. and Sandeman, D.D. (2006) The benefits of oestrogens on postprandial lipid metabolism are lost in post-menopausal women with Type 2 diabetes Diabetic Medicine, 23, (7), pp. 768-774.

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AIMS: Women with Type 2 diabetes appear to lose the protection against cardiovascular disease (CVD) afforded by oestrogens. We examined the effects of oestrogen hormone replacement therapy (HRT) on postprandial clearance of dietary fat in non-diabetic and diabetic post-menopausal women. METHODS: In a cross-sectional study, fasting subjects [HRT+ and HRT- control and diabetic women; Type 2 diabetes (DM) HRT+n = 8, DM HRT-n = 14, control HRT+n = 7, control HRT-n = 11] consumed a meal containing the stable isotope 1,1,1-[13]C-tripalmitin, with blood and breath sampled for 6 and 24 h, respectively, in the postprandial period. RESULTS: In diabetic women, there were no differences between the HRT+ and HRT- groups for any of these parameters. In contrast, in HRT+ compared with HRT- control women, the triglyceride (TG) area under the curve was lower [AUC; HRT+ median (range) 7.7 (4.1, 12.8) mmol/l per 6 h, HRT- 9.7 (3.9, 18.5) mmol/l per 6 h, P < 0.05] and [13]C-palmitic acid in the TG fraction was also lower [HRT+ 23.2 (10.3, 41.3) ng/ml per 6 h, HRT- 47.7 (12.6, 77.2) ng/ml per 6 h, P < 0.05], suggesting the lower postprandial triglyceridaemia associated with HRT in non-diabetic women is because of better chylomicron clearance. CONCLUSIONS: The oestrogen-associated advantage in clearance of dietary lipid we observed in non-diabetic post-menopausal women is not seen in post-menopausal diabetic women. This is likely to promote an atherogenic lipoprotein profile and may contribute to the loss of CVD protection seen in diabetic women.

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Published date: July 2006
Keywords: lipoproteins, oestrogens, postprandial, type 2 diabetes mellitus


Local EPrints ID: 61364
ISSN: 0742-3071
PURE UUID: 24a8b59b-325b-4e06-a688-e669e3679149
ORCID for G.C. Burdge: ORCID iD

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Date deposited: 01 Oct 2008
Last modified: 17 Oct 2017 10:21

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Author: M.G. Masding
Author: A.J. Stears
Author: G.C. Burdge ORCID iD
Author: S.A. Wootton
Author: D.D. Sandeman

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