The University of Southampton
University of Southampton Institutional Repository

Variation in [U-C-13] alpha linolenic acid absorption, beta-oxidation and conversion to docosahexaenoic acid in the pre-term infant fed a DHA-enriched formula

Mayes, Clifford, Burdge, Graham C., Bingham, Anne, Murphy, Jane L., Tubman, Richard and Wootton, Stephen A. (2006) Variation in [U-C-13] alpha linolenic acid absorption, beta-oxidation and conversion to docosahexaenoic acid in the pre-term infant fed a DHA-enriched formula Pediatric Research, 59, (2), pp. 271-275. (doi:10.1203/01.pdr.0000196372.29648.7a).

Record type: Article

Abstract

Docosahexaenoic acid (DHA) is an integral component of neural cell membranes and is critical to the development and function of the CNS. A premature delivery interrupts normal placental supply of DHA such that the infant is dependent oil the nature of the nutritional Support offered. The most abundant omega-3 fatty acid in pre-term formulas is a linolenic acid (ALNA), the precursor of DHA. This project studied the absorption, beta-oxidation and conversion of ALNA to DHA by pre-term infants ranging from 30-37 wk of corrected gestation. [U-C-13] ALNA was administered emulsified with a pre-term formula to 20 well pre-term infants oil full enteral feeds. Enrichment of C-13 in stool and as (CO2)-C-13 in breath was used to estimate absorption across the gut and partitioning toward beta-oxidation respectively. Excretion of the administered dose of C-13 in stool ranged from 2.0 to 26.2%; excretion decreased with increasing birth gestation. Appearance as (CO2)-C-13 on breath ranged from 7.6 to 19.0%. All infants synthesised eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and DHA with the least mature having the highest cumulative plasma DHA. These results show considerable variation suggesting that the worst absorption of ALNA and the greatest production of DHA occur in infants born at the earliest gestation

Full text not available from this repository.

More information

Published date: February 2006
Keywords: function, metabolism, child, membrane, preterm, plasma, fatty acid, cell membrane, eicosapentaenoic acid, infant, research, time, women, term, nutritional support, premature-infant, human, docosahexaenoic acid, polyunsaturated fatty-acids, development, acid, tissues, birth, men, conversion, oil, england

Identifiers

Local EPrints ID: 61365
URI: http://eprints.soton.ac.uk/id/eprint/61365
ISSN: 0031-3998
PURE UUID: d061110a-e6f6-4a6c-af60-e2da09972754
ORCID for Graham C. Burdge: ORCID iD orcid.org/0000-0002-7665-2967

Catalogue record

Date deposited: 08 Sep 2008
Last modified: 17 Jul 2017 14:22

Export record

Altmetrics

Contributors

Author: Clifford Mayes
Author: Anne Bingham
Author: Jane L. Murphy
Author: Richard Tubman

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×