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In vitro fertilization improves childhood growth and metabolism

Miles, Harriet L., Hofman, Paul L., Peek, John, Harris, Mark, Wilson, Dyanne, Robinson, Elizabeth M., Gluckman, Peter D. and Cutfield, Wayne S. (2007) In vitro fertilization improves childhood growth and metabolism Journal of Clinical Endocrinology and Metabolism, 92, (9), pp. 3441-3445. (doi:10.1210/jc.2006-2465).

Record type: Article

Abstract

BACKGROUND: There is limited information regarding the long-term outcome of children born after in vitro fertilization (IVF), although an increase in rare imprinted gene disorders such as Beckwith-Wiedemann syndrome has been reported.
METHODS: We recruited healthy, prepubertal children born at term after singleton pregnancy. The children in the study group were conceived using IVF with fresh embryo transfer, whereas controls were naturally conceived. Anthropometric measurements, bone age, dual-energy x-ray absorptiometry, fasting serum glucose, insulin, lipid profile, IGF-I and -II, and IGF-binding proteins 1, 2, and 3 were performed.
RESULTS: There were 69 IVF children aged 5.9 +/- 0.2 yr and 71 control children aged 6.9 yr. IVF children were taller than controls when corrected for parents' heights (height sd score of 1.05 +/- 0.1 vs. 0.51 +/- 0.11, P = 0.001) with higher levels of serum IGF-II (850 +/- 24 vs. 773 +/- 24 microg/liter, P = 0.03), higher IGF-I to IGF-binding protein 3 ratio (P = 0.04), and a trend toward higher IGF-I (105 +/- 4 vs. 92 +/- 4 microg/liter, P = 0.06). IVF children had higher high-density lipoprotein (1.67 +/- 0.04 mmol/liter vs. 1.53 +/- 0.04 mmol/liter, P = 0.02), lower triglycerides (0.65 +/- 0.04 mmol/liter vs. 0.78 +/- 0.04 mmol/liter, P = 0.02), and a lower total to high-density lipoprotein cholesterol ratio (2.58 vs. 2.86, P = 0.01). There were no differences in body composition.
CONCLUSIONS: IVF children are taller with higher IGF-I and IGF-II levels and have a slightly more favorable lipid profile. We speculate that IVF results in epigenetic change through altered methylation of genes involved in growth and metabolism. IVF programs should consider long-term longitudinal follow-up of IVF offspring.

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More information

Published date: 2007
Keywords: child, body mass index, insulin, fasting, protein, in-vitro, embryo, metabolism, human, growth, analysis, insulin-like growth factor i, male, cholesterol, fertilization in vitro, physiology, methods, height, triglycerides, child development, development, insulin-like growth factor binding proteins, case-control studies, parents, bone, binding, proteins, blood, research, body composition, glucose, age determination by skeleton, humans, female, childhood, gene, aged, preschool, epigenetic, pregnancy, syndrome, body height

Identifiers

Local EPrints ID: 61378
URI: http://eprints.soton.ac.uk/id/eprint/61378
ISSN: 0021-972X
PURE UUID: 6d277626-2597-4ff4-b475-e042a6721d67

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Date deposited: 04 Sep 2008
Last modified: 17 Jul 2017 14:22

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Contributors

Author: Harriet L. Miles
Author: Paul L. Hofman
Author: John Peek
Author: Mark Harris
Author: Dyanne Wilson
Author: Elizabeth M. Robinson
Author: Peter D. Gluckman
Author: Wayne S. Cutfield

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