The University of Southampton
University of Southampton Institutional Repository

Decreased tumor growth in Walker 256 tumor-bearing rats chronically supplemented with fish oil involves COX-2 and PGE2 reduction associated with apoptosis and increased peroxidation

Mund, Rogéria C., Pizato, Nathalia, Bonatto, Sandro, Nunes, Everson A., Vicenzi, Thiago, Tanhoffer, Ricardo, de Oliveira, Heloisa H.P., Curi, Rui, Calder, Philip C. and Fernandes, Luiz C. (2007) Decreased tumor growth in Walker 256 tumor-bearing rats chronically supplemented with fish oil involves COX-2 and PGE2 reduction associated with apoptosis and increased peroxidation Prostaglandins, Leukotrienes and Essential Fatty Acids, 76, (2), pp. 113-120. (doi:10.1016/j.plefa.2006.11.008).

Record type: Article

Abstract

Many studies have shown that addition of fish oil (FO) to the diet reduces tumor growth but the mechanism(s) of action involved is (are) still unknown. In this study, we examine some possible mechanisms in tumor-bearing rats chronically supplemented with FO. Male Wistar rats (21 days old) were fed with regular chow and supplemented with coconut or FO (1g/kg body weight) until they reached 70 days of age. Then, they were inoculated with a suspension of Walker 256 ascitic tumor cells (2 x 10(7)ml) and after 14 days they were killed. Supplementation with FO resulted in significantly lower tumor weight, greater tumor cell apoptosis, lower ex vivo tumor cell proliferation, a higher tumor content of lipid peroxides, lower expression of cyclooxygenase-2 (COX-2) in tumor tissue and a lower plasma concentration of prostaglandin E2 than observed in rats fed regular chow or supplemented with coconut oil. These results suggest that reduction of tumor growth by FO involves an increase in apoptosis and of lipid peroxidation in tumor tissue, with a reduction in tumor cell proliferation ex vivo, COX-2 expression and PGE2 production. Thus, FO may act simultaneously through multiple effects to reduce tumor growth. Whether these effects are connected through a single underlying mechanism remains to be seen.

Full text not available from this repository.

More information

Published date: February 2007

Identifiers

Local EPrints ID: 61392
URI: http://eprints.soton.ac.uk/id/eprint/61392
PURE UUID: 69d2e2fc-2758-4f65-86f9-865c981ff54f

Catalogue record

Date deposited: 30 Sep 2008
Last modified: 17 Jul 2017 14:22

Export record

Altmetrics

Contributors

Author: Rogéria C. Mund
Author: Nathalia Pizato
Author: Sandro Bonatto
Author: Everson A. Nunes
Author: Thiago Vicenzi
Author: Ricardo Tanhoffer
Author: Heloisa H.P. de Oliveira
Author: Rui Curi
Author: Luiz C. Fernandes

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×