Mesenchymal stem cells: lineage, plasticity and skeletal therapeutic potential
Mesenchymal stem cells: lineage, plasticity and skeletal therapeutic potential
The tremendous capacity of bone to regenerate is indicative of the presence of stem cells with the capability, by definition, to self-renew as well as to give rise to daughter cells. These primitive progenitors, termed mesenchymal stem cells or bone marrow stromal stem cells, exist postnatally, and are multipotent with the ability to generate cartilage, bone, muscle, tendon, ligament, and fat. Given the demographic challenge of an ageing population, the development of strategies to exploit the potential of stem cells to augment bone formation to replace or restore the function of traumatized, diseased, or degenerated bone is a major clinical and socioeconomic need. Owing to the developmental plasticity of mesenchymal stem cells, there is great interest in their application to replace damaged tissues. Combined with modern advances in gene therapy and tissue engineering, they have the potential to improve the quality of life for many. Critical in the development of this field will be an understanding of the phenotype, plasticity, and potentiality of these cells and the tempering of patients' expectations driven by commercial and media hype to match current laboratory and clinical observations.
osteoprogenitor, bone regeneration, cell therapy, mesenchymal stem cell, tissue engineering, osteoblast, marrow stromal cells, regenerative medicine
169-178
Oreffo, Richard O.C.
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Cooper, Cyrus
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Mason, Christopher
2011d8aa-069d-4b9c-b084-37887fc06cdc
Clements, Mark
105f1f09-3434-43c6-b122-2770216d6d76
June 2005
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Mason, Christopher
2011d8aa-069d-4b9c-b084-37887fc06cdc
Clements, Mark
105f1f09-3434-43c6-b122-2770216d6d76
Oreffo, Richard O.C., Cooper, Cyrus, Mason, Christopher and Clements, Mark
(2005)
Mesenchymal stem cells: lineage, plasticity and skeletal therapeutic potential.
Stem Cell Reviews and Reports, 1 (2), .
(doi:10.1385/SCR:1:2:169).
Abstract
The tremendous capacity of bone to regenerate is indicative of the presence of stem cells with the capability, by definition, to self-renew as well as to give rise to daughter cells. These primitive progenitors, termed mesenchymal stem cells or bone marrow stromal stem cells, exist postnatally, and are multipotent with the ability to generate cartilage, bone, muscle, tendon, ligament, and fat. Given the demographic challenge of an ageing population, the development of strategies to exploit the potential of stem cells to augment bone formation to replace or restore the function of traumatized, diseased, or degenerated bone is a major clinical and socioeconomic need. Owing to the developmental plasticity of mesenchymal stem cells, there is great interest in their application to replace damaged tissues. Combined with modern advances in gene therapy and tissue engineering, they have the potential to improve the quality of life for many. Critical in the development of this field will be an understanding of the phenotype, plasticity, and potentiality of these cells and the tempering of patients' expectations driven by commercial and media hype to match current laboratory and clinical observations.
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Published date: June 2005
Keywords:
osteoprogenitor, bone regeneration, cell therapy, mesenchymal stem cell, tissue engineering, osteoblast, marrow stromal cells, regenerative medicine
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Local EPrints ID: 61406
URI: http://eprints.soton.ac.uk/id/eprint/61406
ISSN: 1550-8943
PURE UUID: 370337bf-f79f-441e-92d8-929c085773d5
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Date deposited: 06 Oct 2008
Last modified: 18 Mar 2024 02:51
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Author:
Christopher Mason
Author:
Mark Clements
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