The University of Southampton
University of Southampton Institutional Repository

Maternal nutrition during gestation and carotid arterial compliance in the adult offspring: the Dutch famine birth cohort

Record type: Article

OBJECTIVE: Experimental evidence indicates that maternal undernutrition during gestation may program hypertension in the offspring. We investigated whether maternal undernutrition leads to increased arterial stiffness. METHODS: We measured carotid artery lumen diameter (LD), distensibility (DC), stiffness (beta), and compliance (CC) by M-mode ultrasound in 673 individuals, aged 56-61 years, who had been born as term singletons around the time of the 1944-45 Dutch famine. RESULTS: Maternal famine exposure had no effect on any of the measures of carotid size or stiffness in the offspring. Low maternal weight at the end of pregnancy and low birth weight were associated with decreased LD (0.01 mm/kg maternal weight, sex-adjusted P < 0.001; 0.1 mm/kg birth weight, sex-adjusted P = 0.08) and CC (0.002 mm/kPa per kg maternal weight, sex-adjusted P = 0.001; 0.03 mm/kPa per kg birth weight, sex-adjusted P = 0.03), but neither was associated with increased beta, or decreased DC. These effects were not attenuated by adjusting for maternal protein/carbohydrate ratio in the third trimester. The association of low birth weight with increased CC diminished after adjusting for maternal weight. The association of maternal weight with CC was smaller when adjusted for LD. CONCLUSION: Our findings suggest that small maternal size, not poor maternal diet, in late gestation programs decreased arterial compliance in the adult offspring by affecting vessel size rather than vessel wall stiffness.

Full text not available from this repository.

Citation

Painter, Rebecca C., de Rooij, Susanne R., Bossuyt, Patrick M., de Groot, Eric, Stok, Wim J., Osmond, Clive, Barker, David J., Bleker, Otto P. and Roseboom, Tessa J. (2007) Maternal nutrition during gestation and carotid arterial compliance in the adult offspring: the Dutch famine birth cohort Journal of Hypertension, 25, (3), pp. 533-540.

More information

Published date: March 2007

Identifiers

Local EPrints ID: 61418
URI: http://eprints.soton.ac.uk/id/eprint/61418
ISSN: 0263-6352
PURE UUID: 1216ab87-2935-4d8f-9063-728fab62017f
ORCID for Clive Osmond: ORCID iD orcid.org/0000-0002-9054-4655

Catalogue record

Date deposited: 01 Oct 2008
Last modified: 17 Jul 2017 14:22

Export record

Contributors

Author: Rebecca C. Painter
Author: Susanne R. de Rooij
Author: Patrick M. Bossuyt
Author: Eric de Groot
Author: Wim J. Stok
Author: Clive Osmond ORCID iD
Author: David J. Barker
Author: Otto P. Bleker
Author: Tessa J. Roseboom

University divisions


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×