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Effect of iron supplementation on physical growth in children: systematic review of randomised controlled trials

Sachdev, H.P.S., Gera, Tarun and Nestel, Penelope (2006) Effect of iron supplementation on physical growth in children: systematic review of randomised controlled trials Public Health Nutrition, 9, (7), pp. 904-920. (doi:10.1017/PHN2005918).

Record type: Article


OBJECTIVE: To evaluate the effect of iron supplementation on physical growth in children through a systematic review of randomised controlled trials (RCTs). DATA SOURCES: Electronic databases, personal files, and hand search of reviews, bibliographies of books, abstracts and proceedings of international conferences. REVIEW METHODS: RCTs evaluating change in anthropometry with interventions that included oral or parenteral iron supplementation, or iron-fortified formula milk or cereals, were analysed. RESULTS: Twenty-five trials (26 cohorts) had relevant information. There was no evidence of publication bias. The pooled estimates (random effects model) did not document a statistically significant (P>0.05) positive effect of iron supplementation on any anthropometric variable (weight-for-age, weight-for-height, height-for-age, mid upper-arm circumference, skinfold thickness, head circumference). Significant heterogeneity was evident, and its predictors included greater weight-for-age in supplemented children in malaria hyperendemic regions and greater weight-for-height for children above 5 years of age, but a negative effect on linear growth in developed countries and with supplementation for 6 months or longer. CONCLUSIONS: This review did not document a positive effect of iron supplementation on the physical growth of children. The identified predictors of heterogeneity should be considered as exploratory and requiring confirmation, not conclusive.

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Published date: October 2006
Keywords: anaemia, anthropometry, growth, height-for-age, iron deficiency, iron supplementation, meta-analysis, randomised controlled trials, weight-for-age, weight-for-height


Local EPrints ID: 61486
ISSN: 1368-9800
PURE UUID: fb2146f4-8233-4635-a83f-f6c3f54e2591

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Date deposited: 02 Oct 2008
Last modified: 17 Jul 2017 14:21

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Author: H.P.S. Sachdev
Author: Tarun Gera
Author: Penelope Nestel

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