Osteoporosis: trends in epidemiology, pathogenesis and treatment

Sambrook, P. and Cooper, C. (2006) Osteoporosis: trends in epidemiology, pathogenesis and treatment. The Lancet, 367 (9527), 2010-2018. (doi:10.1016/S0140-6736(06)68891-0).

Record type: Article

Abstract

Osteoporosis is a serious public health issue. The past 10 years have seen great advances in our understanding of its epidemiology, pathophysiology, and treatment, and further advances are rapidly being made. Clinical assessment will probably evolve from decisions mainly being made on the basis of bone densitometry, to use of algorithms of absolute fracture risk. Biochemical markers of bone turnover are also likely to become more widely used. Bisphosphonates will probably remain the mainstay of therapy, but improved understanding of the optimum amount of remodelling suppression and duration of therapy will be important. At the same time, other diagnostic and therapeutic approaches, including biological agents, are likely to become more widespread.

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Published date: 2006

Keywords: calcium, physiology, drug therapy, bone, osteoporosis, densitometry, physiopathology, fractures, vitamin d, complications, public health, bone density, health, bone density conservation agents, epidemiology, time, therapeutic use, trends, drug effects, middle aged, review, bone remodeling, therapy, risk, humans, diphosphonates, female, algorithms, aged, etiology, risk factors

Organisations: Dev Origins of Health & Disease