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Grip strength and the metabolic syndrome: findings from the Hertfordshire cohort study

Grip strength and the metabolic syndrome: findings from the Hertfordshire cohort study
Grip strength and the metabolic syndrome: findings from the Hertfordshire cohort study
INTRODUCTION: Sarcopenia, the loss of muscle mass and strength with age, is significantly associated with type 2 diabetes in older people. AIM: To determine whether there is a relationship between grip strength and features of the metabolic syndrome.
DESIGN: Cross-sectional study.
METHODS: Data were collected on grip strength, fasting glucose, triglycerides and HDL cholesterol, blood pressure, waist circumference and 2 h glucose after an oral glucose tolerance test, in a population-based sample of 2677 men and women aged 59-73 years.
RESULTS: In men and women combined, a standard deviation (SD) decrease in grip strength was significantly associated with higher: fasting triglycerides (0.05 SD unit increase, 95%CI 0.02-0.09, p = 0.006); blood pressure (OR 1.13, 95%CI 1.04-1.24, p = 0.004); waist circumference (0.08 SD unit increase, 95%CI 0.06-0.10, p < 0.001); 2 h glucose (0.07 SD unit increase, 95%CI 0.03-0.11, p = 0.001) and HOMA resistance (0.05 SD unit increase, 95%CI 0.01-0.09, p = 0.008), after adjustment for gender, weight, age, walking speed, social class, smoking habit and alcohol intake. Lower grip strength was also significantly associated with increased odds of having the metabolic syndrome according to both the ATPIII (OR 1.18, 95%CI 1.07-1.30, p < 0.001) and IDF definitions (OR 1.11, 95%CI 1.01-1.22, p = 0.03).
DISCUSSION: Our findings suggest that impaired grip strength is associated with the individual features, as well as with the overall summary definitions, of the metabolic syndrome. The potential for grip strength to be used in the clinical setting needs to be explored.
glucose, cohort, alcohol, blood pressure, blood, metabolic syndrome, muscle, glucose tolerance test, weight, cross-sectional studies, syndrome, Hertfordshire, cholesterol, triglycerides, fasting, epidemiology, smoking, walking, diabetes, cardiovascular disease, methods, aged, women, cohort studies, social class, glucose tolerance
1460-2725
707-713
Sayer, A.A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Syddall, H.E.
a0181a93-8fc3-4998-a996-7963f0128328
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Martin, H.J.
34384528-4b85-41c3-95dc-16ade10aaf44
Phillips, D.I.
29b73be7-2ff9-4fff-ae42-d59842df4cc6
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Byrne, C.D.
1370b997-cead-4229-83a7-53301ed2a43c
Sayer, A.A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Syddall, H.E.
a0181a93-8fc3-4998-a996-7963f0128328
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Martin, H.J.
34384528-4b85-41c3-95dc-16ade10aaf44
Phillips, D.I.
29b73be7-2ff9-4fff-ae42-d59842df4cc6
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Byrne, C.D.
1370b997-cead-4229-83a7-53301ed2a43c

Sayer, A.A., Syddall, H.E., Dennison, E.M., Martin, H.J., Phillips, D.I., Cooper, C. and Byrne, C.D. (2007) Grip strength and the metabolic syndrome: findings from the Hertfordshire cohort study. QJM: An International Journal of Medicine, 100 (11), 707-713. (doi:10.1093/qjmed/hcm095).

Record type: Article

Abstract

INTRODUCTION: Sarcopenia, the loss of muscle mass and strength with age, is significantly associated with type 2 diabetes in older people. AIM: To determine whether there is a relationship between grip strength and features of the metabolic syndrome.
DESIGN: Cross-sectional study.
METHODS: Data were collected on grip strength, fasting glucose, triglycerides and HDL cholesterol, blood pressure, waist circumference and 2 h glucose after an oral glucose tolerance test, in a population-based sample of 2677 men and women aged 59-73 years.
RESULTS: In men and women combined, a standard deviation (SD) decrease in grip strength was significantly associated with higher: fasting triglycerides (0.05 SD unit increase, 95%CI 0.02-0.09, p = 0.006); blood pressure (OR 1.13, 95%CI 1.04-1.24, p = 0.004); waist circumference (0.08 SD unit increase, 95%CI 0.06-0.10, p < 0.001); 2 h glucose (0.07 SD unit increase, 95%CI 0.03-0.11, p = 0.001) and HOMA resistance (0.05 SD unit increase, 95%CI 0.01-0.09, p = 0.008), after adjustment for gender, weight, age, walking speed, social class, smoking habit and alcohol intake. Lower grip strength was also significantly associated with increased odds of having the metabolic syndrome according to both the ATPIII (OR 1.18, 95%CI 1.07-1.30, p < 0.001) and IDF definitions (OR 1.11, 95%CI 1.01-1.22, p = 0.03).
DISCUSSION: Our findings suggest that impaired grip strength is associated with the individual features, as well as with the overall summary definitions, of the metabolic syndrome. The potential for grip strength to be used in the clinical setting needs to be explored.

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More information

Published date: 2007
Keywords: glucose, cohort, alcohol, blood pressure, blood, metabolic syndrome, muscle, glucose tolerance test, weight, cross-sectional studies, syndrome, Hertfordshire, cholesterol, triglycerides, fasting, epidemiology, smoking, walking, diabetes, cardiovascular disease, methods, aged, women, cohort studies, social class, glucose tolerance

Identifiers

Local EPrints ID: 61498
URI: http://eprints.soton.ac.uk/id/eprint/61498
DOI: doi:10.1093/qjmed/hcm095
ISSN: 1460-2725
PURE UUID: 566fb032-5171-40ce-a85f-29803948632c
ORCID for H.E. Syddall: ORCID iD orcid.org/0000-0003-0171-0306
ORCID for E.M. Dennison: ORCID iD orcid.org/0000-0002-3048-4961
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for C.D. Byrne: ORCID iD orcid.org/0000-0001-6322-7753

Catalogue record

Date deposited: 10 Sep 2008
Last modified: 18 Mar 2024 02:50

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Contributors

Author: A.A. Sayer
Author: H.E. Syddall ORCID iD
Author: E.M. Dennison ORCID iD
Author: H.J. Martin
Author: D.I. Phillips
Author: C. Cooper ORCID iD
Author: C.D. Byrne ORCID iD

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