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Lupin allergy in peanut-allergic children and teenagers

Record type: Article

Background: Lupin has now been introduced into food production in the UK. There is a concern that, on account of cross-reactivity, peanut-allergic children are at high risk for lupin allergy. AIMS: To investigate the prevalence of lupin sensitization and allergy in children with peanut allergy compared with atopic controls.

Methods: Children (<18 years) were recruited. Peanut-allergic subjects either had a convincing history of peanut allergy with diagnostic peanut skin prick test (SPT) or specific-immunoglobulin E (IgE) results or a positive food challenge. Control subjects were atopic but not peanut-allergic. All subjects had SPT to peanut and lupin. Sensitized subjects were offered a randomized, double-blind, placebo-controlled lupin challenge. Lupin allergy was defined as objective immediate hypersensitivity reaction at food challenge.

Results: Forty-seven peanut-allergic children and 46 atopic controls were recruited. Sixteen peanut-allergic children were sensitized to lupin [34%, 95% confidence interval (CI): 21-49%]. Nine were challenged to lupin. Two reacted (itchy mouth and urticaria; itchy mouth and 20% drop in peak expiratory flow rate) giving a minimum prevalence of lupin allergy in peanut-allergic children of 4.0% (95% CI: 1-15%). Atopic controls were significantly (P = 0.001) less likely to be sensitized to lupin (4%, 95% CI: 1-15%) and had smaller wheals and serum-specific IgE results. None of the atopic controls reacted on lupin challenge, giving a rate of allergy in the atopic controls of 0% (95% CI: 0-8%).

Conclusions: A small but significant number of children with peanut allergy are allergic to lupin. Sensitization to lupin is much rarer in nonpeanut-allergic atopic subjects.

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Citation

Shaw, J., Roberts, G., Grimshaw, K., White, S. and Hourihane, J. (2008) Lupin allergy in peanut-allergic children and teenagers Allergy, 63, (3), pp. 370-373. (doi:10.1111/j.1398-9995.2007.01568.x).

More information

e-pub ahead of print date: 19 November 2007
Published date: March 2008
Keywords: health, immunology, preschool, risk, humans, food hypersensitivity, peanut hypersensitivity, female, immunization, immunoglobulin e, probability, child, reference values, male, allergens, adolescent, confidence intervals, great britain, diagnostic use, adverse effects, etiology, methods, risk assessment, lupinus, prevalence, diagnosis, double-blind method, sensitivity and specificity, skin tests

Identifiers

Local EPrints ID: 61509
URI: http://eprints.soton.ac.uk/id/eprint/61509
ISSN: 0105-4538
PURE UUID: e4f91c6b-8bdb-4b08-a4a4-3c17a425fdc9

Catalogue record

Date deposited: 02 Sep 2008
Last modified: 17 Jul 2017 14:21

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Contributors

Author: J. Shaw
Author: G. Roberts
Author: K. Grimshaw
Author: S. White
Author: J. Hourihane

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