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Effect of annual intramuscular vitamin D on fracture risk in elderly men and women: a population-based, randomized, double-blind, placebo-controlled trial

Record type: Article

OBJECTIVES: Low trauma fractures in older people incur enormous physical, social and economic costs. Previous research indicates that an annual intramuscular injection of vitamin D may reduce fracture rates in this group. This strategy requires validation in a population setting. METHODS: Randomized, double-blind, placebo-controlled trial of 300,000 IU intramuscular (i.m.) vitamin D2 (ergocalciferol) injection or matching placebo every autumn over 3 years. 9440 people (4354 men and 5086 women) aged 75 yrs and over were recruited from general practice registers in Wessex, England. Primary outcome measure was all non-vertebral fracture. Secondary outcomes were hip and wrist fractures, and all falls. RESULTS: 585 subjects had incident non-spine fractures (hip 110, wrist 116, ankle 37). Hazard ratios (HRs) for fracture in the vitamin D group were: 1.09 [95% confidence interval (CI) 0.93-1.28, P = 0.29] for any first fracture, 1.49 (95% CI 1.02-2.18, P = 0.04) for hip and 1.22 (95% CI 0.85-1.76, P = 0.28) for wrist. There was no effect on falls: HR 0.98 (0.93-1.04). No protective effect was observed in any subgroup when the cohort was stratified by sex, age, previous fracture or mobility. CONCLUSIONS: An annual i.m. injection of 300,000 IU vitamin D2 is not effective in preventing non-vertebral fractures among elderly men and women resident in the general population.

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Citation

Smith, H., Anderson, F., Raphael, H., Maslin, P., Crozier, S. and Cooper, C. (2007) Effect of annual intramuscular vitamin D on fracture risk in elderly men and women: a population-based, randomized, double-blind, placebo-controlled trial Rheumatology, 46, (12), pp. 1852-1857. (doi:10.1093/rheumatology/kem240).

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Published date: December 2007

Identifiers

Local EPrints ID: 61523
URI: http://eprints.soton.ac.uk/id/eprint/61523
ISSN: 1462-0324
PURE UUID: af09a353-168e-4164-8e1c-6e239af2239b

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Date deposited: 02 Oct 2008
Last modified: 17 Jul 2017 14:21

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Contributors

Author: H. Smith
Author: F. Anderson
Author: H. Raphael
Author: P. Maslin
Author: S. Crozier
Author: C. Cooper

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