The University of Southampton
University of Southampton Institutional Repository

Transmission of raised blood pressure and endothelial dysfunction to the F2 generation induced by maternal protein restriction in the F0, in the absence of dietary challenge in the F1 generation

Record type: Article

We have previously demonstrated that maternal protein restriction during pregnancy leads to raised blood pressure and endothelial dysfunction in the offspring (F1). Here we show that these characteristics are transmitted to the F2 offspring through the maternal line, in the absence of any additional challenges to the F1. Female Wistar rats were fed either a control (18 % casein) or protein-restricted diet (PR; 9 % casein) throughout pregnancy. Female F1 offspring, maintained on standard chow postpartum, were mated with breeding males to produce F2 progeny. Systolic blood pressure (SBP) in male F2 offspring was assessed by tail-cuff plethysmography at age 100 d and vascular function of small mesenteric arteries by wire myography at age 80 and 200 d. SBP was raised in PR F2 offspring compared with controls (control 122.1 (sem 2.3) mmHg, n 7; PR 134.7 (sem 3.2) mmHg, n 6; P < 0.01) and endothelial function, assessed by vasodilatation to acetylcholine, was impaired at both age 80 d (% maximal response: control 89.7 (sem 2.6), n 14; PR 72.7 (sem 4.4), n 15; P < 0.01) and 200 d (effective concentration equal to 50 % of maximum (pEC50): control 7.67 (sem 0.10), n 10; PR 7.33 (sem 0.07), n 8; P < 0.05). The present study demonstrates that both raised blood pressure and endothelial dysfunction are passed via the maternal line to grand-offspring in the absence of any additional dietary challenges to their F1 mothers. Risk factors for chronic disease may therefore be heritable by non-genomic processes.

Full text not available from this repository.

Citation

Torrens, Christopher, Poston, Lucilla and Hanson, Mark A. (2008) Transmission of raised blood pressure and endothelial dysfunction to the F2 generation induced by maternal protein restriction in the F0, in the absence of dietary challenge in the F1 generation British Journal of Nutrition, 100, (4), pp. 760-766. (doi:10.1017/S0007114508921747). (PMID:18304387).

More information

Published date: October 2008
Keywords: function, diet, female, rats, breeding, chronic disease, blood, vascular, maternal, pressure, blood pressure, risk factors, rat, fetal, mothers, protein, male, physiology, risk, pregnancy, blood-pressure, disease

Identifiers

Local EPrints ID: 61566
URI: http://eprints.soton.ac.uk/id/eprint/61566
ISSN: 0007-1145
PURE UUID: 08543551-5ea7-4df3-91fd-57588120b0b1

Catalogue record

Date deposited: 09 Sep 2008
Last modified: 17 Jul 2017 14:21

Export record

Altmetrics


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×