Muscle microvascular filtration capacity and blood flow in metabolic syndrome
Muscle microvascular filtration capacity and blood flow in metabolic syndrome
Metabolic syndrome is a combination of risk factors that increase risk of cardiovascular disease (CVD) and diabetes. We
have assessed muscle microvascular function in 38 consented volunteers [52+/-9y, n=17 male] with two or more features of
metabolic syndrome (central obesity, dyslipidaemia, high blood pressure and dysglycaemia), before and after 6 months lipid
lowering therapy (Atorvastatin 40mg o.d.) or placebo control. Filtration capacity (Kf), isovolumetric pressure (Pvi) and resting
limb blood flow (Qa) were measured using strain gauge plethysmography (FiltrassAngio®, Compumedics.dwl, Germany). At
baseline, Kf was negatively correlated with overall CVD risk, visceral fat, insulin resistance, LDL Cholesterol, HbA1c,markers
of inflammation and age (r>0.4, p<0.05), and positively correlated with HDL cholesterol. Qa was related to activity (r=0.42,
p=0.03). These individuals also showed a marked decrease in dilator capacity. While statins lowered LDL cholesterol
(P<0.0001), they had little effect on any of our microvascular measures. These data suggest an attenuation in capacity for
blood/tissue exchange in people with features of metabolic syndrome. Although statins are known to decrease risk of CVD,
we were unable to show any improvements in microvascular function over the 6 months study.
blood-flow, syndrome, muscle, blood flow, metabolic syndrome, blood
p.645
Walter, L.
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Turzyniecka, M.
b289ca34-c265-4ce0-93e5-efdb015cd24a
Byrne, C.D.
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Gamble, J.
cd1c0206-caae-4847-adc9-ddf7e48ac7ed
Clough, G.F.
9f19639e-a929-4976-ac35-259f9011c494
2007
Walter, L.
f0a14d57-c095-4bb7-a7c2-30f6160a3a27
Turzyniecka, M.
b289ca34-c265-4ce0-93e5-efdb015cd24a
Byrne, C.D.
1370b997-cead-4229-83a7-53301ed2a43c
Gamble, J.
cd1c0206-caae-4847-adc9-ddf7e48ac7ed
Clough, G.F.
9f19639e-a929-4976-ac35-259f9011c494
Walter, L., Turzyniecka, M., Byrne, C.D., Gamble, J. and Clough, G.F.
(2007)
Muscle microvascular filtration capacity and blood flow in metabolic syndrome.
Microcirculation, 14 (6), .
Record type:
Meeting abstract
Abstract
Metabolic syndrome is a combination of risk factors that increase risk of cardiovascular disease (CVD) and diabetes. We
have assessed muscle microvascular function in 38 consented volunteers [52+/-9y, n=17 male] with two or more features of
metabolic syndrome (central obesity, dyslipidaemia, high blood pressure and dysglycaemia), before and after 6 months lipid
lowering therapy (Atorvastatin 40mg o.d.) or placebo control. Filtration capacity (Kf), isovolumetric pressure (Pvi) and resting
limb blood flow (Qa) were measured using strain gauge plethysmography (FiltrassAngio®, Compumedics.dwl, Germany). At
baseline, Kf was negatively correlated with overall CVD risk, visceral fat, insulin resistance, LDL Cholesterol, HbA1c,markers
of inflammation and age (r>0.4, p<0.05), and positively correlated with HDL cholesterol. Qa was related to activity (r=0.42,
p=0.03). These individuals also showed a marked decrease in dilator capacity. While statins lowered LDL cholesterol
(P<0.0001), they had little effect on any of our microvascular measures. These data suggest an attenuation in capacity for
blood/tissue exchange in people with features of metabolic syndrome. Although statins are known to decrease risk of CVD,
we were unable to show any improvements in microvascular function over the 6 months study.
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More information
Published date: 2007
Keywords:
blood-flow, syndrome, muscle, blood flow, metabolic syndrome, blood
Organisations:
Dev Origins of Health & Disease
Identifiers
Local EPrints ID: 61592
URI: http://eprints.soton.ac.uk/id/eprint/61592
ISSN: 1073-9688
PURE UUID: 9a00c577-9719-49c3-a29f-125d33e95f9a
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Date deposited: 03 Apr 2009
Last modified: 16 Mar 2024 03:08
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Contributors
Author:
L. Walter
Author:
M. Turzyniecka
Author:
J. Gamble
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