The University of Southampton
×
Filter your search:
University of Southampton Institutional Repository

Immune modulation by parenteral lipid emulsions

Immune modulation by parenteral lipid emulsions
Immune modulation by parenteral lipid emulsions
Total parenteral nutrition is the final option for nutritional support of patients with severe intestinal failure. Lipid emulsions constitute the main source of fuel calories and fatty acids (FAs) in parenteral nutrition formulations. However, adverse effects on patient outcomes have been attributed to the use of lipids, mostly in relation to impaired immune defenses and altered inflammatory responses. Over the years, this issue has remained in the limelight, also because technical advances have provided no safeguard against the most daunting problems, ie, infectious complications. Nevertheless, numerous investigations have failed to produce a clear picture of the immunologic characteristics of the most commonly used soybean oil-derived lipid emulsions, although their high content of n-6 polyunsaturated FAs (PUFAs) has been considered a drawback because of their proinflammatory potential. This concern initiated the development of emulsions in which part of the n-6 FA component is replaced by less bioactive FAs, such as coconut oil (rich in medium-chain saturated FAs) or olive oil (rich in the n-9 monounsaturated FA oleic acid). Another approach has been to use fish oil (rich in n-3 PUFA), the FAs of which have biological activities different from those of n-6 PUFAs. Recent studies on the modulation of host defenses and inflammation by fish-oil emulsions have yielded consistent data, which indicate that these emulsions may provide a tool to beneficially alter the course of immune-mediated conditions. Although most of these lipids have not yet become available on the US market, this review synthesizes available information on immunologic characteristics of the different lipids that currently can be applied via parenteral nutrition support
omega-6, lipids, plant oils, fat emulsions, physiology, fish oils, review, metabolism, total, soybean oil, omega-3, immunology, adverse effects, methods, inflammation, administration & dosage, fatty acids, intravenous, parenteral nutrition, nutritional support, oils, lipid metabolism, netherlands, chemistry, unsaturated, dietary fats, drug effects, immune system, nutrition, complications, acid, membrane lipids, humans, activity
0002-9165
1171-1184
Wanten, G.J.
21dec8f0-9460-4599-b966-641e9af90195
Calder, P.C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Wanten, G.J.
21dec8f0-9460-4599-b966-641e9af90195
Calder, P.C.
1797e54f-378e-4dcb-80a4-3e30018f07a6

Wanten, G.J. and Calder, P.C. (2007) Immune modulation by parenteral lipid emulsions. American Journal of Clinical Nutrition, 85 (5), 1171-1184.

Record type: Review

Abstract

Total parenteral nutrition is the final option for nutritional support of patients with severe intestinal failure. Lipid emulsions constitute the main source of fuel calories and fatty acids (FAs) in parenteral nutrition formulations. However, adverse effects on patient outcomes have been attributed to the use of lipids, mostly in relation to impaired immune defenses and altered inflammatory responses. Over the years, this issue has remained in the limelight, also because technical advances have provided no safeguard against the most daunting problems, ie, infectious complications. Nevertheless, numerous investigations have failed to produce a clear picture of the immunologic characteristics of the most commonly used soybean oil-derived lipid emulsions, although their high content of n-6 polyunsaturated FAs (PUFAs) has been considered a drawback because of their proinflammatory potential. This concern initiated the development of emulsions in which part of the n-6 FA component is replaced by less bioactive FAs, such as coconut oil (rich in medium-chain saturated FAs) or olive oil (rich in the n-9 monounsaturated FA oleic acid). Another approach has been to use fish oil (rich in n-3 PUFA), the FAs of which have biological activities different from those of n-6 PUFAs. Recent studies on the modulation of host defenses and inflammation by fish-oil emulsions have yielded consistent data, which indicate that these emulsions may provide a tool to beneficially alter the course of immune-mediated conditions. Although most of these lipids have not yet become available on the US market, this review synthesizes available information on immunologic characteristics of the different lipids that currently can be applied via parenteral nutrition support

This record has no associated files available for download.

More information

Published date: 2007
Related URLs:
Keywords: omega-6, lipids, plant oils, fat emulsions, physiology, fish oils, review, metabolism, total, soybean oil, omega-3, immunology, adverse effects, methods, inflammation, administration & dosage, fatty acids, intravenous, parenteral nutrition, nutritional support, oils, lipid metabolism, netherlands, chemistry, unsaturated, dietary fats, drug effects, immune system, nutrition, complications, acid, membrane lipids, humans, activity
Learn more about Medicine research

Identifiers

Local EPrints ID: 61593
URI: http://eprints.soton.ac.uk/id/eprint/61593
ISSN: 0002-9165
PURE UUID: 524b4ac8-326a-4dcb-a081-24c1819c2e0f
ORCID for P.C. Calder: ORCID iD orcid.org/0000-0002-6038-710X

Catalogue record

Date deposited: 08 Sep 2008
Last modified: 31 May 2023 01:33

Export record

Contributors

Author: G.J. Wanten
Author: P.C. Calder ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Library staff additional information
Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×