The University of Southampton
University of Southampton Institutional Repository

Determinants of outcomes after head cooling for neonatal encephalopathy

Wyatt, John S., Gluckman, Peter D., Liu, Ping Y., Azzopardi, Denis, Ballard, Roberta, Edwards, A. David, Ferriero, Donna M., Polin, Richard A., Robertson, Charlene M., Thoresen, Marianne, Whitelaw, Andrew and Gunn, Alistair J. (2007) Determinants of outcomes after head cooling for neonatal encephalopathy Pediatrics, 119, (5), pp. 912-921. (doi:10.1542/peds.2006-2839).

Record type: Article


OBJECTIVE: The goal of this study was to evaluate the role of factors that may determine the efficacy of treatment with delayed head cooling and mild systemic hypothermia for neonatal encephalopathy. METHODS: A total of 218 term infants with moderate to severe neonatal encephalopathy plus abnormal amplitude-integrated electroencephalographic recordings, assigned randomly to head cooling for 72 hours, starting within 6 hours after birth (with the rectal temperature maintained at 34.5 +/- 0.5 degrees C), or conventional care, were studied. Death or severe disability at 18 months of age was assessed in a multicenter, randomized, controlled study (the CoolCap trial). RESULTS: Treatment, lower encephalopathy grade, lower birth weight, greater amplitude-integrated electroencephalographic amplitude, absence of seizures, and higher Apgar score, but not gender or gestational age, were associated significantly with better outcomes. In a multivariate analysis, each of the individually predictive factors except for Apgar score remained predictive. There was a significant interaction between treatment and birth weight, categorized as > or =25th or or =38 degrees C) in control infants was associated with adverse outcomes. Although there was a small correlation with birth weight, the adverse effect of greater birth weight in control infants remained significant after adjustment for pyrexia and severity of encephalopathy. CONCLUSIONS: Outcomes after hypothermic treatment were strongly influenced by the severity of neonatal encephalopathy. The protective effect of hypothermia was greater in larger infants

Full text not available from this repository.

More information

Published date: 5 May 2007
Keywords: neonatal encephalopathy, hypoxic/ischemic encephalopathy, induced hypothermia, birth weight, pyrexia


Local EPrints ID: 61618
ISSN: 0031-4005
PURE UUID: 4f8e7d86-ec18-4ebd-b13b-9f1f37fee63f

Catalogue record

Date deposited: 08 Sep 2008
Last modified: 17 Jul 2017 14:21

Export record



Author: John S. Wyatt
Author: Peter D. Gluckman
Author: Ping Y. Liu
Author: Denis Azzopardi
Author: Roberta Ballard
Author: A. David Edwards
Author: Donna M. Ferriero
Author: Richard A. Polin
Author: Charlene M. Robertson
Author: Marianne Thoresen
Author: Andrew Whitelaw
Author: Alistair J. Gunn

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.