Fatty acids and immune function: new insights into mechanisms
Fatty acids and immune function: new insights into mechanisms
Fatty acids are known to play diverse roles in immune cells. They are important as a source of energy, as structural components of cell membranes, as signaling molecules and as precursors for the synthesis of eicosanoids and similar mediators. Recent research has suggested that the localization and organisation of fatty acids into distinct cellular pools has a direct influence on the behaviour of a number of proteins involved in immune cell activation, including those associated with T cell responses, antigen presentation and fatty acid-derived inflammatory mediator production. This article reviews these studies and places them in the context of existing literature in the field. These studies indicate the existence of several novel mechanisms by which altered fatty acid availability can modulate immune responses and impact upon clinical outcomes.
fatty acid, fish oil, omega-3, eicosanoid, lipid raft, t cell, lymphocyte, antigen presentation, lipid body, inflammation
S41-S45
Yaqoob, Parveen
3a418e24-bbf0-4b31-9df8-ca8514885c82
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
October 2007
Yaqoob, Parveen
3a418e24-bbf0-4b31-9df8-ca8514885c82
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Yaqoob, Parveen and Calder, Philip C.
(2007)
Fatty acids and immune function: new insights into mechanisms.
British Journal of Nutrition, 98 (Supplement S1), .
(doi:10.1017/S0007114507832995).
Abstract
Fatty acids are known to play diverse roles in immune cells. They are important as a source of energy, as structural components of cell membranes, as signaling molecules and as precursors for the synthesis of eicosanoids and similar mediators. Recent research has suggested that the localization and organisation of fatty acids into distinct cellular pools has a direct influence on the behaviour of a number of proteins involved in immune cell activation, including those associated with T cell responses, antigen presentation and fatty acid-derived inflammatory mediator production. This article reviews these studies and places them in the context of existing literature in the field. These studies indicate the existence of several novel mechanisms by which altered fatty acid availability can modulate immune responses and impact upon clinical outcomes.
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Published date: October 2007
Keywords:
fatty acid, fish oil, omega-3, eicosanoid, lipid raft, t cell, lymphocyte, antigen presentation, lipid body, inflammation
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Local EPrints ID: 61627
URI: http://eprints.soton.ac.uk/id/eprint/61627
ISSN: 0007-1145
PURE UUID: cbe09692-85d6-403e-ab2d-8421c609d34a
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Date deposited: 07 Oct 2008
Last modified: 16 Mar 2024 02:51
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Author:
Parveen Yaqoob
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