Fatty acids and immune function: new insights into mechanisms

Yaqoob, Parveen and Calder, Philip C. (2007) Fatty acids and immune function: new insights into mechanisms British Journal of Nutrition, 98, (Supplement S1), S41-S45. (doi:10.1017/S0007114507832995).


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Fatty acids are known to play diverse roles in immune cells. They are important as a source of energy, as structural components of cell membranes, as signaling molecules and as precursors for the synthesis of eicosanoids and similar mediators. Recent research has suggested that the localization and organisation of fatty acids into distinct cellular pools has a direct influence on the behaviour of a number of proteins involved in immune cell activation, including those associated with T cell responses, antigen presentation and fatty acid-derived inflammatory mediator production. This article reviews these studies and places them in the context of existing literature in the field. These studies indicate the existence of several novel mechanisms by which altered fatty acid availability can modulate immune responses and impact upon clinical outcomes.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1017/S0007114507832995
ISSNs: 0007-1145 (print)
Related URLs:
Keywords: fatty acid, fish oil, omega-3, eicosanoid, lipid raft, t cell, lymphocyte, antigen presentation, lipid body, inflammation
ePrint ID: 61627
Date :
Date Event
October 2007Published
Date Deposited: 07 Oct 2008
Last Modified: 16 Apr 2017 17:30
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/61627

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