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Prediction of outcome from the chest radiograph appearance on day 7 of very prematurely born infants

Greenough, Anne, Thomas, Mark, Dimitriou, Gabriel, Williams, Olivia, Johnson, Alice, Limb, Elizabeth, Peacock, Janet, Marlow, Neil and Calvert, Sandra (2004) Prediction of outcome from the chest radiograph appearance on day 7 of very prematurely born infants European Journal of Pediatrics, 163, (1), pp. 14-18. (doi:10.1007/s00431-003-1332-6).

Record type: Article


Our aim was to determine whether the chest radiograph appearance at 7 days predicted chronic lung disease development (oxygen dependency at 36 weeks post-menstrual age) or death before discharge and if it was a better predictor than readily available clinical data. Two consecutive studies were performed. In both, chest radiographs taken at 7 days for clinical purposes were assessed using a scoring system for the presence of fibrosis/interstitial shadows, cystic elements and hyperinflation and data were collected regarding gestational age, birth weight, use of antenatal steroids and postnatal surfactant and requirement for ventilation at 7 days. Oxygenation indices were calculated in the first study (study A) at 120 h and in the second (study B) at 168 h. In study A, there were 59 infants with a median gestational age of 26 weeks (range 24 to 28 weeks) and in study B, 40 infants with a median gestational age of 27 weeks (range 25-31 weeks). In both studies, infants who developed chronic lung disease had a significantly higher total chest radiograph score, with a higher score for fibrosis/interstitial shadowing than the rest of the cohort. Infants who died before discharge differed significantly from the rest with regard to significantly higher scores for cysts. In both studies, the areas under the receiver operator characteristic curves with regard to prediction of chronic lung disease were higher for the total chest radiograph score compared to those for readily available clinical data. Conclusion: In infants who require a chest radiograph for clinical purposes at 7 days, the chest radiograph appearance can facilitate prediction of outcome of infants born very prematurely.

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Published date: January 2004
Keywords: cohort, steroids, chronic lung-disease, disease, england, time, weight, oxygen, london, birth, chest radiograph, chronic lung disease, gestational age, prediction, child, chronic, infant, birth weight, lung


Local EPrints ID: 61802
ISSN: 0340-6199
PURE UUID: f5ef2cfd-df2c-41bf-a368-f39d54d9c866

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Date deposited: 10 Sep 2008
Last modified: 17 Jul 2017 14:21

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Author: Anne Greenough
Author: Mark Thomas
Author: Gabriel Dimitriou
Author: Olivia Williams
Author: Alice Johnson
Author: Elizabeth Limb
Author: Janet Peacock
Author: Neil Marlow
Author: Sandra Calvert

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