Issues with using baseline in last observation carried forward analysis
Issues with using baseline in last observation carried forward analysis
The topic of this paper was prompted by a study for which one of us was the statistician. It was submitted to Annals of Internal Medicine. The paper had positive reviewer comment; however, the statistical reviewer stated that for the analysis to be acceptable for publication, the missing data had to be accounted for in the analysis through the use of baseline in a last observation carried forward imputation. We discuss the issues associated with this form of imputation and recommend that it should not be undertaken as a primary analysis.
missing data, england, clinical-trials, paper, imputation, time, baselines, observation, analysis, locf
142-146
Julious, Steven A.
e70c3d71-b62d-41a8-8e98-df954f127935
Mullee, Mark A.
fd3f91c3-5e95-4f56-8d73-260824eeb362
April 2008
Julious, Steven A.
e70c3d71-b62d-41a8-8e98-df954f127935
Mullee, Mark A.
fd3f91c3-5e95-4f56-8d73-260824eeb362
Julious, Steven A. and Mullee, Mark A.
(2008)
Issues with using baseline in last observation carried forward analysis.
Pharmaceutical Statistics, 7 (2), .
(doi:10.1002/pst.311).
Abstract
The topic of this paper was prompted by a study for which one of us was the statistician. It was submitted to Annals of Internal Medicine. The paper had positive reviewer comment; however, the statistical reviewer stated that for the analysis to be acceptable for publication, the missing data had to be accounted for in the analysis through the use of baseline in a last observation carried forward imputation. We discuss the issues associated with this form of imputation and recommend that it should not be undertaken as a primary analysis.
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Published date: April 2008
Keywords:
missing data, england, clinical-trials, paper, imputation, time, baselines, observation, analysis, locf
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Local EPrints ID: 61843
URI: http://eprints.soton.ac.uk/id/eprint/61843
ISSN: 1539-1604
PURE UUID: 86d12776-6759-4682-acb8-1b7f7f8e2e34
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Date deposited: 16 Sep 2008
Last modified: 15 Mar 2024 11:28
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Author:
Steven A. Julious
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