Julious, Steven A. and Mullee, Mark A.
Issues with using baseline in last observation carried forward analysis
Pharmaceutical Statistics, 7, (2), . (doi:10.1002/pst.311).
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The topic of this paper was prompted by a study for which one of us was the statistician. It was submitted to Annals of Internal Medicine. The paper had positive reviewer comment; however, the statistical reviewer stated that for the analysis to be acceptable for publication, the missing data had to be accounted for in the analysis through the use of baseline in a last observation carried forward imputation. We discuss the issues associated with this form of imputation and recommend that it should not be undertaken as a primary analysis.
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