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Issues with using baseline in last observation carried forward analysis

Julious, Steven A. and Mullee, Mark A. (2008) Issues with using baseline in last observation carried forward analysis Pharmaceutical Statistics, 7, (2), pp. 142-146. (doi:10.1002/pst.311).

Record type: Article


The topic of this paper was prompted by a study for which one of us was the statistician. It was submitted to Annals of Internal Medicine. The paper had positive reviewer comment; however, the statistical reviewer stated that for the analysis to be acceptable for publication, the missing data had to be accounted for in the analysis through the use of baseline in a last observation carried forward imputation. We discuss the issues associated with this form of imputation and recommend that it should not be undertaken as a primary analysis.

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Published date: April 2008
Keywords: missing data, england, clinical-trials, paper, imputation, time, baselines, observation, analysis, locf


Local EPrints ID: 61843
ISSN: 1539-1604
PURE UUID: 86d12776-6759-4682-acb8-1b7f7f8e2e34

Catalogue record

Date deposited: 16 Sep 2008
Last modified: 17 Jul 2017 14:21

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