Issues with using baseline in last observation carried forward analysis


Julious, Steven A. and Mullee, Mark A. (2008) Issues with using baseline in last observation carried forward analysis Pharmaceutical Statistics, 7, (2), pp. 142-146. (doi:10.1002/pst.311).

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Description/Abstract

The topic of this paper was prompted by a study for which one of us was the statistician. It was submitted to Annals of Internal Medicine. The paper had positive reviewer comment; however, the statistical reviewer stated that for the analysis to be acceptable for publication, the missing data had to be accounted for in the analysis through the use of baseline in a last observation carried forward imputation. We discuss the issues associated with this form of imputation and recommend that it should not be undertaken as a primary analysis.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1002/pst.311
ISSNs: 1539-1604 (print)
Keywords: missing data, england, clinical-trials, paper, imputation, time, baselines, observation, analysis, locf
Subjects:
ePrint ID: 61843
Date :
Date Event
April 2008Published
Date Deposited: 16 Sep 2008
Last Modified: 16 Apr 2017 17:30
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/61843

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