Landolfo, Francesca, Saiki, Tolulope, Peacock, Janet, Hannam, Simon, Rafferty, Gerrard F. and Greenough, Anne
Hering-Breuer reflex, lung volume and position in prematurely born infants
Pediatric Pulmonology, 43, (8), . (doi:10.1002/ppul.20855). (PMID:18618620).
Full text not available from this repository.
OBJECTIVES: To investigate the effect of position on the strength of the Hering-Breuer reflex in prematurely born infants and determine whether any differences seen were related to differences in lung or tidal volume between positions. WORKING HYPOTHESIS: Position related differences in the strength of the Hering-Breuer reflex relate to differences in lung or tidal volume.
STUDY DESIGN: Prospective observational study. PATIENT/SUBJECT SELECTION: Eighteen infants, median gestational age 30 (range 25-32) weeks were studied. METHODOLOGY: Infants were examined in the supine and prone position, each position was maintained for 2 hr. At the end of each 2-hr period, the strength of the Hering-Breuer reflex was assessed by determining the prolongation of expiration following an end inspiratory occlusion. In addition, tidal volume and functional residual capacity (FRC) were assessed in each position.
RESULTS: The strength of the Hering-Breuer reflex was greater (P = 0.01) and the mean FRC was higher (P < 0.0001) in the prone compared to the supine position. The position related differences in the strength of the reflex correlated significantly with position related differences in FRC (P = 0.05). CONCLUSIONS: The Hering-Breuer reflex is stronger in the prone compared to the supine position. Our results suggest this is explained by position related differences in lung volume.
|Digital Object Identifier (DOI):
||asthma, lung, design, infant, research support, gestational age, london, biology, functional residual capacity, research, strength, hypothesis
||16 Sep 2008
||16 Apr 2017 17:30
|Further Information:||Google Scholar|
Actions (login required)