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Hering-Breuer reflex, lung volume and position in prematurely born infants

Landolfo, Francesca, Saiki, Tolulope, Peacock, Janet, Hannam, Simon, Rafferty, Gerrard F. and Greenough, Anne (2008) Hering-Breuer reflex, lung volume and position in prematurely born infants Pediatric Pulmonology, 43, (8), pp. 767-771. (PMID:18618620).

Record type: Article

Abstract

OBJECTIVES: To investigate the effect of position on the strength of the Hering-Breuer reflex in prematurely born infants and determine whether any differences seen were related to differences in lung or tidal volume between positions. WORKING HYPOTHESIS: Position related differences in the strength of the Hering-Breuer reflex relate to differences in lung or tidal volume.
STUDY DESIGN: Prospective observational study. PATIENT/SUBJECT SELECTION: Eighteen infants, median gestational age 30 (range 25-32) weeks were studied. METHODOLOGY: Infants were examined in the supine and prone position, each position was maintained for 2 hr. At the end of each 2-hr period, the strength of the Hering-Breuer reflex was assessed by determining the prolongation of expiration following an end inspiratory occlusion. In addition, tidal volume and functional residual capacity (FRC) were assessed in each position.
RESULTS: The strength of the Hering-Breuer reflex was greater (P = 0.01) and the mean FRC was higher (P < 0.0001) in the prone compared to the supine position. The position related differences in the strength of the reflex correlated significantly with position related differences in FRC (P = 0.05). CONCLUSIONS: The Hering-Breuer reflex is stronger in the prone compared to the supine position. Our results suggest this is explained by position related differences in lung volume.

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More information

Published date: August 2008
Keywords: asthma, lung, design, infant, research support, gestational age, london, biology, functional residual capacity, research, strength, hypothesis

Identifiers

Local EPrints ID: 61899
URI: http://eprints.soton.ac.uk/id/eprint/61899
ISSN: 8755-6863
PURE UUID: 975d93f4-3bdb-4cd5-91f9-f2ab1bfd7cc8

Catalogue record

Date deposited: 16 Sep 2008
Last modified: 10 Sep 2017 22:03

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Contributors

Author: Francesca Landolfo
Author: Tolulope Saiki
Author: Janet Peacock
Author: Simon Hannam
Author: Gerrard F. Rafferty
Author: Anne Greenough

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