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Penicillin for acute sore throat in children: randomised, double blind trial

Penicillin for acute sore throat in children: randomised, double blind trial
Penicillin for acute sore throat in children: randomised, double blind trial
Objective: To assess the effectiveness of penicillin for three days and treatment for seven days compared with placebo in resolving symptoms in children with sore throat.
Design: Randomised, double blind, placebo controlled trial.
Setting: 43 family practices in the Netherlands.
Participants: 156 children aged 4-15 who had a sore throat for less than seven days and at least two of the four Centor criteria (history of fever, absence of cough, swollen tender anterior cervical lymph nodes, and tonsillar exudate). Interventions Patients were randomly assigned to penicillin for seven days, penicillin for three days followed by placebo for four days, or placebo for seven days.
Main outcome measures: Duration of symptoms, mean consumption of analgesics, number of days of absence from school, occurrence of streptococcal sequelae, eradication of the initial pathogen, and recurrences of sore throat after six months. Results Penicillin treatment was not more beneficial than placebo in resolving symptoms of sore throat, neither in the total group nor in the 96 children with group A streptococci. In the groups randomised to seven days of penicillin, three days of penicillin, or placebo, one, two, and eight children, respectively, experienced a streptococcal sequela.
Conclusion: Penicillin treatment had no beneficial effect in children with sore throat on the average duration of symptoms. Penicillin may, however, reduce streptococcal sequelae.
therapeutic use, health, drug therapy, pharyngitis, double-blind, humans, penicillins
0959-8138
1327-1328
Little, P.
1bf2d1f7-200c-47a5-ab16-fe5a8756a777
Little, P.
1bf2d1f7-200c-47a5-ab16-fe5a8756a777

Little, P. (2003) Penicillin for acute sore throat in children: randomised, double blind trial. BMJ, 327 (7427), 1327-1328. (doi:10.1136/bmj.327.7427.1324).

Record type: Article

Abstract

Objective: To assess the effectiveness of penicillin for three days and treatment for seven days compared with placebo in resolving symptoms in children with sore throat.
Design: Randomised, double blind, placebo controlled trial.
Setting: 43 family practices in the Netherlands.
Participants: 156 children aged 4-15 who had a sore throat for less than seven days and at least two of the four Centor criteria (history of fever, absence of cough, swollen tender anterior cervical lymph nodes, and tonsillar exudate). Interventions Patients were randomly assigned to penicillin for seven days, penicillin for three days followed by placebo for four days, or placebo for seven days.
Main outcome measures: Duration of symptoms, mean consumption of analgesics, number of days of absence from school, occurrence of streptococcal sequelae, eradication of the initial pathogen, and recurrences of sore throat after six months. Results Penicillin treatment was not more beneficial than placebo in resolving symptoms of sore throat, neither in the total group nor in the 96 children with group A streptococci. In the groups randomised to seven days of penicillin, three days of penicillin, or placebo, one, two, and eight children, respectively, experienced a streptococcal sequela.
Conclusion: Penicillin treatment had no beneficial effect in children with sore throat on the average duration of symptoms. Penicillin may, however, reduce streptococcal sequelae.

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More information

Published date: 2003
Keywords: therapeutic use, health, drug therapy, pharyngitis, double-blind, humans, penicillins

Identifiers

Local EPrints ID: 61953
URI: http://eprints.soton.ac.uk/id/eprint/61953
ISSN: 0959-8138
PURE UUID: 3d5c96b0-d461-4ab6-aba3-4df1eb7c8a45

Catalogue record

Date deposited: 03 Sep 2008
Last modified: 09 Jan 2022 08:44

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