The University of Southampton
University of Southampton Institutional Repository

End-tidal carbon monoxide levels in prematurely born infants developing bronchopulmonary dysplasia

End-tidal carbon monoxide levels in prematurely born infants developing bronchopulmonary dysplasia
End-tidal carbon monoxide levels in prematurely born infants developing bronchopulmonary dysplasia
Bronchopulmonary dysplasia (BPD) is associated with an early inflammatory response that persists after the first week of life. Inflammatory mediators can induce hemoxygenase-1 with a consequent increase in carbon monoxide (CO) production. End-tidal CO (ETCO) levels would be elevated in infants developing BPD. Serial measurements of ETCO levels were attempted on d 3, 5, 7, 14, 21, and 28 in 50 prematurely born infants (median gestational age 29 wk). Fourteen infants developed BPD [oxygen dependent beyond 36 wk post-menstrual age (PMA)] and had higher ETCO levels compared with the rest of the cohort on d 7, 14, 21, and 28. On d 14, the mean (SD) ETCO levels of the BPD group were 3.19 (1.11) ppm and 1.43 (0.61) ppm in the non-BPD group (p 2.15 ppm had a sensitivity of 80% and specificity of 92% in predicting oxygen dependency at 36 wk PMA. Measurement of ETCO levels in prematurely born infants may be useful in the prediction of BPD
time, care, asthma, children, infant, oxygen, inflammation, england, chronic lung-disease, gestational age, ventilated preterm infants, bilirubin production, london, lung, exhaled nitric-oxide, term infants, cohort, prediction, nasal, research, smoking
0031-3998
474-478
May, Caroline
e66fa767-3ca4-42c8-84a3-1f5ae47ba2f4
Patel, Sabina
adb79122-a9ee-48af-818f-5a2b608e889e
Peacock, Janet
62df4239-ae7e-44cf-aa3c-3c2e7f1e511c
Milner, Anthony
a4f4f685-513a-4d7b-8472-8c68441927cd
Rafferty, Gerrard F.
4ecc9b30-5f92-41d2-8598-b72029c00062
Greenough, Anne
5fb7521d-ae58-4a58-9a0b-deddcf1647c2
May, Caroline
e66fa767-3ca4-42c8-84a3-1f5ae47ba2f4
Patel, Sabina
adb79122-a9ee-48af-818f-5a2b608e889e
Peacock, Janet
62df4239-ae7e-44cf-aa3c-3c2e7f1e511c
Milner, Anthony
a4f4f685-513a-4d7b-8472-8c68441927cd
Rafferty, Gerrard F.
4ecc9b30-5f92-41d2-8598-b72029c00062
Greenough, Anne
5fb7521d-ae58-4a58-9a0b-deddcf1647c2

May, Caroline, Patel, Sabina, Peacock, Janet, Milner, Anthony, Rafferty, Gerrard F. and Greenough, Anne (2007) End-tidal carbon monoxide levels in prematurely born infants developing bronchopulmonary dysplasia. Pediatric Research, 61 (4), 474-478. (doi:10.1203/pdr.0b013e3180332bfe).

Record type: Article

Abstract

Bronchopulmonary dysplasia (BPD) is associated with an early inflammatory response that persists after the first week of life. Inflammatory mediators can induce hemoxygenase-1 with a consequent increase in carbon monoxide (CO) production. End-tidal CO (ETCO) levels would be elevated in infants developing BPD. Serial measurements of ETCO levels were attempted on d 3, 5, 7, 14, 21, and 28 in 50 prematurely born infants (median gestational age 29 wk). Fourteen infants developed BPD [oxygen dependent beyond 36 wk post-menstrual age (PMA)] and had higher ETCO levels compared with the rest of the cohort on d 7, 14, 21, and 28. On d 14, the mean (SD) ETCO levels of the BPD group were 3.19 (1.11) ppm and 1.43 (0.61) ppm in the non-BPD group (p 2.15 ppm had a sensitivity of 80% and specificity of 92% in predicting oxygen dependency at 36 wk PMA. Measurement of ETCO levels in prematurely born infants may be useful in the prediction of BPD

This record has no associated files available for download.

More information

Published date: April 2007
Keywords: time, care, asthma, children, infant, oxygen, inflammation, england, chronic lung-disease, gestational age, ventilated preterm infants, bilirubin production, london, lung, exhaled nitric-oxide, term infants, cohort, prediction, nasal, research, smoking

Identifiers

Local EPrints ID: 61981
URI: http://eprints.soton.ac.uk/id/eprint/61981
ISSN: 0031-3998
PURE UUID: 341fa6a0-b89e-49ee-97a7-c21aeb612ba5

Catalogue record

Date deposited: 08 Sep 2008
Last modified: 15 Mar 2024 11:28

Export record

Altmetrics

Contributors

Author: Caroline May
Author: Sabina Patel
Author: Janet Peacock
Author: Anthony Milner
Author: Gerrard F. Rafferty
Author: Anne Greenough

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×