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The clinical grading of Raynaud's phenomenon and vibration-induced white finger: Relationship between finger blanching and difficulties in using the upper limb

Palmer, Keith T., Griffin, Michael J., Syddall, Holly, Cooper, Cyrus and Coggon, David (2002) The clinical grading of Raynaud's phenomenon and vibration-induced white finger: Relationship between finger blanching and difficulties in using the upper limb International Archives of Occupational and Environmental Health, 75, (1-2), pp. 29-36. (doi:10.1007/s004200100275).

Record type: Article


Objectives: To investigate the association between functional difficulties in using the upper limb and extent and frequency of finger blanching, and the merits of these markers in grading the severity of Raynaud's phenomenon (RP) and vibration-induced white finger (VWF).

Methods: A questionnaire was mailed to a randomly selected community sample of 22,194 working-aged adults. Information was collected on cold-induced finger blanching - including the extent and frequency of attacks in the past year, and on difficulty in using the upper limb in several everyday activities (e.g. doing up buttons, opening a tight screw-top jar, and pouring from a jug). Associations were examined by logistic regression with the resultant odds ratios converted into prevalence ratios (PRs) and 95% confidence intervals (95% CI).

Results: Among 12,907 respondents were 1,359 who reported finger blanching and provided details of its extent and frequency. Of these, 7.4% reported frequent attacks (50 or more over the year), and 12% reported extensive blanching (affecting nine or ten digits). After adjustment for potential confounders, subjects with finger blanching reported an excess of difficulties in using the limb. Thus, in men with blanching the PR for difficulty with buttons was 4.7 (95% CI 3.9-5.8), and that for pouring from a jug was 3.8 (3.0-4.9) in comparison with men who had never had blanching. Similar associations were found in women and in those men with exposure to hand-transmitted vibration. The risk of reporting difficulties increased markedly with frequency of blanching - up to four- or fivefold in those with 50 or more attacks in the past year compared with those who had none; but differences by extent were less marked, with PRs h1.6 in those with nine to ten digits affected compared with one to two digits.

Conclusions: RP and VWF are both associated with difficulties in using the upper limb in everyday tasks. Further investigation of potential reporting biases is warranted, but if the associations are causal, frequency of attacks influences impairment more than extent of disease. More account may need to be taken of frequency of blanching episodes in assessing and in compensating subjects with VWF.

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Published date: January 2002
Keywords: Blanching, Grading, Severity, Upper limb function
Organisations: University of Southampton


Local EPrints ID: 62023
ISSN: 0340-0131
PURE UUID: 87c51503-ab15-462e-867a-fdd7433ed113
ORCID for Michael J. Griffin: ORCID iD
ORCID for Cyrus Cooper: ORCID iD
ORCID for David Coggon: ORCID iD

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Date deposited: 10 Sep 2008
Last modified: 17 Jul 2017 14:21

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Author: Keith T. Palmer
Author: Holly Syddall
Author: Cyrus Cooper ORCID iD
Author: David Coggon ORCID iD

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