A systematic review of vanadium oral supplements for glycaemic control in type 2 diabetes mellitus
A systematic review of vanadium oral supplements for glycaemic control in type 2 diabetes mellitus
Objective: To assess the effectiveness of oral vanadium supplementation for glycaemic control in type 2 diabetes by conducting a systematic review of the literature.
Design and Methods: Eligible studies were identified by searching 14 databases using standardized terms. Experts, study authors and manufacturers were also contacted. Hand-searching was not undertaken. Selection criteria for inclusion in the review were controlled human trials of vanadium vs. placebo in adults with type 2 diabetes of minimum 2 months duration, and a minimum of 10 subjects per arm. Data extraction, assessment of study quality and outcome analysis were undertaken by two independent reviewers.
Results: One hundred and fifty one studies were found but none met the inclusion criteria. We proceeded to summarize the state of existing evidence and plan for a future clinical trial by applying revised, less restrictive criteria to our search, for clinical trials of 30150 mg daily oral vanadium supplementation in diabetic humans. Only five were identified. These demonstrated significant treatment-effects, but due to poor study quality, must be interpreted with caution. Treatment with vanadium often results in gastrointestinal side-effects.
Conclusion: There is no rigorous evidence that oral vanadium supplementation improves glycaemic control in type 2 diabetes. The routine use of vanadium for this purpose cannot be recommended. A large-scale randomized controlled trial is needed to address this clinical question.
risk, databases, diabetes mellitus, insulin sensitivity, adults, sulfate, analysis, time, adult, micronutrients, human, diabetes, review, methods, arm, clinical-trials, placebo, controlled-trial, quality, trial, literature, clinical trials, humans, clinical-trial, treatment, England, design
351-358
Smith, D.M.
88dfac94-ed7d-438d-9581-3dce369e9882
Pickering, R.M.
4a828314-7ddf-4f96-abed-3407017d4c90
Lewith, G.T.
0fc483fa-f17b-47c5-94d9-5c15e65a7625
2008
Smith, D.M.
88dfac94-ed7d-438d-9581-3dce369e9882
Pickering, R.M.
4a828314-7ddf-4f96-abed-3407017d4c90
Lewith, G.T.
0fc483fa-f17b-47c5-94d9-5c15e65a7625
Smith, D.M., Pickering, R.M. and Lewith, G.T.
(2008)
A systematic review of vanadium oral supplements for glycaemic control in type 2 diabetes mellitus.
QJM: An International Journal of Medicine, 101 (5), .
(doi:10.1093/qjmed/hcn003).
Abstract
Objective: To assess the effectiveness of oral vanadium supplementation for glycaemic control in type 2 diabetes by conducting a systematic review of the literature.
Design and Methods: Eligible studies were identified by searching 14 databases using standardized terms. Experts, study authors and manufacturers were also contacted. Hand-searching was not undertaken. Selection criteria for inclusion in the review were controlled human trials of vanadium vs. placebo in adults with type 2 diabetes of minimum 2 months duration, and a minimum of 10 subjects per arm. Data extraction, assessment of study quality and outcome analysis were undertaken by two independent reviewers.
Results: One hundred and fifty one studies were found but none met the inclusion criteria. We proceeded to summarize the state of existing evidence and plan for a future clinical trial by applying revised, less restrictive criteria to our search, for clinical trials of 30150 mg daily oral vanadium supplementation in diabetic humans. Only five were identified. These demonstrated significant treatment-effects, but due to poor study quality, must be interpreted with caution. Treatment with vanadium often results in gastrointestinal side-effects.
Conclusion: There is no rigorous evidence that oral vanadium supplementation improves glycaemic control in type 2 diabetes. The routine use of vanadium for this purpose cannot be recommended. A large-scale randomized controlled trial is needed to address this clinical question.
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Published date: 2008
Keywords:
risk, databases, diabetes mellitus, insulin sensitivity, adults, sulfate, analysis, time, adult, micronutrients, human, diabetes, review, methods, arm, clinical-trials, placebo, controlled-trial, quality, trial, literature, clinical trials, humans, clinical-trial, treatment, England, design
Identifiers
Local EPrints ID: 62134
URI: http://eprints.soton.ac.uk/id/eprint/62134
ISSN: 1460-2725
PURE UUID: 7034dedc-7881-4dab-a15b-2aa11d0028f2
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Date deposited: 10 Sep 2008
Last modified: 15 Mar 2024 11:29
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Author:
D.M. Smith
Author:
G.T. Lewith
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