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Plethysmograph and interrupter resistance measurements in prematurely born young children. [In: Fetal and Neonatal Edition]

Thomas, M.R., Rafferty, G.F., Blowes, R., Peacock, J.L., Marlow, N., Calvert, S., Milner, A. and Greenough, A. (2006) Plethysmograph and interrupter resistance measurements in prematurely born young children. [In: Fetal and Neonatal Edition] Archives of Disease in Childhood - Fetal and Neonatal Edition, 91, (3), F193-F196. (doi:10.1136/adc.2005.079608).

Record type: Article


BACKGROUND: Airways obstruction in premature infants is often assessed by plethysmography, which requires sedation. The interrupter (Rint) technique does not require sedation, but has rarely been examined in children under 2 years of age. OBJECTIVE: To compare Rint results with plethysmographic measurements of airway resistance (Raw) in prematurely born, young children. DESIGN: Prospective study. SETTING: Infant and Paediatric Lung Function Laboratories. PATIENTS: Thirty children with a median gestational age of 25-29 weeks and median postnatal age of 13 months. Interventions and MAIN OUTCOME MEASURES: The infants were sedated, airway resistance was measured by total body plethysmography (Raw), and Rint measurements were made using a MicroRint device. Further Raw and Rint measurements were made after salbutamol administration if the children remained asleep. RESULTS: Baseline measurements of Raw and Rint were obtained from 30 and 26 respectively of the children. Mean baseline Rint values were higher than mean baseline Raw results (3.45 v 2.84 kPa/l/s, p = 0.006). Limits of agreement for the mean difference between Rint and Raw were -1.52 to 2.74 kPa/l/s. Ten infants received salbutamol, after which the mean Rint result was 3.6 kPa/l/s and mean Raw was 3.1 kPa/l/s (limits of agreement -0.28 to 1.44 kPa/l/s). CONCLUSION: The poor agreement between Rint and Raw results suggests that Rint measurements cannot substitute for plethysmographic measurements in sedated prematurely born infants.

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Published date: May 2006
Keywords: london, newborn, diseases, airway obstruction, research, health, evaluation studies, functional residual capacity, laboratories, standards, gestational age, whole body, physiology, patients, child, infant, prospective studies, diagnostic use, diagnosis, agents, methods, albuterol, lung, airway resistance, comparative study, resistance, premature, sensitivity and specificity, bronchodilator agents, plethysmography, humans, design, children, research support
Organisations: Medicine


Local EPrints ID: 62159
ISSN: 1359-2998
PURE UUID: bc52fbb3-70f4-4647-a35a-9cf78dc6ad9c

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Date deposited: 03 Sep 2008
Last modified: 17 Jul 2017 14:21

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Author: M.R. Thomas
Author: G.F. Rafferty
Author: R. Blowes
Author: J.L. Peacock
Author: N. Marlow
Author: S. Calvert
Author: A. Milner
Author: A. Greenough

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