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Neuropsychiatric syndromes in dementia. Results from the European Alzheimer Disease Consortium: Part I

Neuropsychiatric syndromes in dementia. Results from the European Alzheimer Disease Consortium: Part I
Neuropsychiatric syndromes in dementia. Results from the European Alzheimer Disease Consortium: Part I
Background/Aims: The aim of this study was to identify neuropsychiatric subsyndromes of the Neuropsychiatric Inventory in a large sample of outpatients with Alzheimer's disease (AD). Methods: Cross-sectional data of 2,354 patients with AD from 12 centres from the European Alzheimer's Disease Consortium were collected. Principal component analysis was used for factor analysis. Results: The results showed the presence of 4 neuropsychiatric subsyndromes: hyperactivity, psychosis, affective symptoms and apathy. The subsyndrome apathy was the most common, occurring in almost 65% of the patients. Conclusion: This large study has provided additional robust evidence for the existence of neuropsychiatric subsyndromes in AD.
neuropsychiatric syndromes, behavioral syndromes, dementia, ad, inventory, depression, disease, symptoms, subsyndromes, disturbance, psychological symptoms, version, alzheimer disease, neuropsychiatric inventory, psychopathology, cache county, care, memory, mild cognitive impairment, apathy, alzheimer's disease, factor analysis
1420-8008
457-463
Aalten, Pauline
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Verhey, Frans R.J.
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Boziki, Marina
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Bullock, Roger
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Byrne, Eleanor Jane
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Camus, Vincent
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Caputo, Miriam
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Collins, Debby
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De Deyn, Peter Paul
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Elina, Kazi
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Frisoni, Giovanni
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Girtler, Nicola
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Holmes, Clive
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Hurt, Catherine
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Marriott, Anna
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Mecocci, Patrizia
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Nobili, Flavio
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Ousset, Pierre Jean
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Reynish, Emma
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Salmon, Eric
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Tsolaki, Magda
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Vellas, Bruno
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Robert, Philippe H.
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Aalten, Pauline
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Verhey, Frans R.J.
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Boziki, Marina
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Bullock, Roger
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Byrne, Eleanor Jane
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Camus, Vincent
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Caputo, Miriam
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Collins, Debby
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De Deyn, Peter Paul
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Elina, Kazi
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Frisoni, Giovanni
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Girtler, Nicola
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Holmes, Clive
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Hurt, Catherine
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Marriott, Anna
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Mecocci, Patrizia
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Nobili, Flavio
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Ousset, Pierre Jean
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Reynish, Emma
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Salmon, Eric
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Tsolaki, Magda
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Vellas, Bruno
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Robert, Philippe H.
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Aalten, Pauline, Verhey, Frans R.J., Boziki, Marina, Bullock, Roger, Byrne, Eleanor Jane, Camus, Vincent, Caputo, Miriam, Collins, Debby, De Deyn, Peter Paul, Elina, Kazi, Frisoni, Giovanni, Girtler, Nicola, Holmes, Clive, Hurt, Catherine, Marriott, Anna, Mecocci, Patrizia, Nobili, Flavio, Ousset, Pierre Jean, Reynish, Emma, Salmon, Eric, Tsolaki, Magda, Vellas, Bruno and Robert, Philippe H. (2007) Neuropsychiatric syndromes in dementia. Results from the European Alzheimer Disease Consortium: Part I. Dementia and Geriatric Cognitive Disorders, 24 (6), 457-463. (doi:10.1159/000110738).

Record type: Article

Abstract

Background/Aims: The aim of this study was to identify neuropsychiatric subsyndromes of the Neuropsychiatric Inventory in a large sample of outpatients with Alzheimer's disease (AD). Methods: Cross-sectional data of 2,354 patients with AD from 12 centres from the European Alzheimer's Disease Consortium were collected. Principal component analysis was used for factor analysis. Results: The results showed the presence of 4 neuropsychiatric subsyndromes: hyperactivity, psychosis, affective symptoms and apathy. The subsyndrome apathy was the most common, occurring in almost 65% of the patients. Conclusion: This large study has provided additional robust evidence for the existence of neuropsychiatric subsyndromes in AD.

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More information

Published date: November 2007
Keywords: neuropsychiatric syndromes, behavioral syndromes, dementia, ad, inventory, depression, disease, symptoms, subsyndromes, disturbance, psychological symptoms, version, alzheimer disease, neuropsychiatric inventory, psychopathology, cache county, care, memory, mild cognitive impairment, apathy, alzheimer's disease, factor analysis

Identifiers

Local EPrints ID: 62224
URI: https://eprints.soton.ac.uk/id/eprint/62224
ISSN: 1420-8008
PURE UUID: 17248c79-b006-42eb-96fa-bcc22d290891
ORCID for Clive Holmes: ORCID iD orcid.org/0000-0003-1999-6912

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Date deposited: 09 Sep 2008
Last modified: 16 Jul 2019 18:31

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Contributors

Author: Pauline Aalten
Author: Frans R.J. Verhey
Author: Marina Boziki
Author: Roger Bullock
Author: Eleanor Jane Byrne
Author: Vincent Camus
Author: Miriam Caputo
Author: Debby Collins
Author: Peter Paul De Deyn
Author: Kazi Elina
Author: Giovanni Frisoni
Author: Nicola Girtler
Author: Clive Holmes ORCID iD
Author: Catherine Hurt
Author: Anna Marriott
Author: Patrizia Mecocci
Author: Flavio Nobili
Author: Pierre Jean Ousset
Author: Emma Reynish
Author: Eric Salmon
Author: Magda Tsolaki
Author: Bruno Vellas
Author: Philippe H. Robert

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