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Effects of topiramate on migraine frequency and cortical excitability in patients with frequent migraine

Effects of topiramate on migraine frequency and cortical excitability in patients with frequent migraine
Effects of topiramate on migraine frequency and cortical excitability in patients with frequent migraine
We studied the excitability of the visual and motor cortex in 36 patients with frequent migraine without aura (30 women, mean age 38.6 +/- 10.0 years) before and after treatment with topiramate (100 mg/day) using transcranial magnetic stimulation. Treatment with topiramate resulted in reduction of both headache frequency (12.0 +/- 1.3 to 5.8 +/- 3.2 migraine days per month; P = 0.004) and cortical excitability: motor cortex thresholds increased on the right side from 43.8 +/- 7.5% to 47.7 +/- 9.2% (P = 0.049) and on the left side from 43.4 +/- 7.0% to 47.2 +/- 9.6% (P = 0.047), and phosphene thresholds increased from 58.9 +/- 11.1% to 71.2 +/- 11.2% (P = 0.0001). Reduction of headache frequency correlated inversely with an increase of visual thresholds and did not correlate with motor thresholds. The effect of topiramate in migraine prevention is complex and can not be explained simply by inhibition of cortical excitability.
motor cortex, treatment, controlled-trial, prevention, migraine, intensity dependence, topiramate, visual-cortex excitability, transcranial magnetic stimulation, habituation, evoked-potentials, prophylaxis, hyperexcitability, cortical excitability
0333-1024
203-208
Artemenko, A.R.
4b49b86d-e7db-4913-8c6b-9f24b842e5f0
Kurenkov, A.L.
a6a51668-de7c-4751-a50c-0908f862dfe0
Filatova, E.G.
79f720f0-8f1d-49e7-995b-8bf9730bef98
Nikitin, S.S.
44964cb0-7fba-4011-8fa3-e19c5c38fb25
Kaube, H.
77be5a18-5ca2-4d97-b90c-0ba9bf978f6d
Katsarava, Z.
2c88871f-d7a7-4424-a9d5-51f2234d1c92
Artemenko, A.R.
4b49b86d-e7db-4913-8c6b-9f24b842e5f0
Kurenkov, A.L.
a6a51668-de7c-4751-a50c-0908f862dfe0
Filatova, E.G.
79f720f0-8f1d-49e7-995b-8bf9730bef98
Nikitin, S.S.
44964cb0-7fba-4011-8fa3-e19c5c38fb25
Kaube, H.
77be5a18-5ca2-4d97-b90c-0ba9bf978f6d
Katsarava, Z.
2c88871f-d7a7-4424-a9d5-51f2234d1c92

Artemenko, A.R., Kurenkov, A.L., Filatova, E.G., Nikitin, S.S., Kaube, H. and Katsarava, Z. (2008) Effects of topiramate on migraine frequency and cortical excitability in patients with frequent migraine. Cephalalgia, 28 (3), 203-208. (doi:10.1111/j.1468-2982.2007.01491.x).

Record type: Article

Abstract

We studied the excitability of the visual and motor cortex in 36 patients with frequent migraine without aura (30 women, mean age 38.6 +/- 10.0 years) before and after treatment with topiramate (100 mg/day) using transcranial magnetic stimulation. Treatment with topiramate resulted in reduction of both headache frequency (12.0 +/- 1.3 to 5.8 +/- 3.2 migraine days per month; P = 0.004) and cortical excitability: motor cortex thresholds increased on the right side from 43.8 +/- 7.5% to 47.7 +/- 9.2% (P = 0.049) and on the left side from 43.4 +/- 7.0% to 47.2 +/- 9.6% (P = 0.047), and phosphene thresholds increased from 58.9 +/- 11.1% to 71.2 +/- 11.2% (P = 0.0001). Reduction of headache frequency correlated inversely with an increase of visual thresholds and did not correlate with motor thresholds. The effect of topiramate in migraine prevention is complex and can not be explained simply by inhibition of cortical excitability.

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More information

Published date: 2008
Keywords: motor cortex, treatment, controlled-trial, prevention, migraine, intensity dependence, topiramate, visual-cortex excitability, transcranial magnetic stimulation, habituation, evoked-potentials, prophylaxis, hyperexcitability, cortical excitability

Identifiers

Local EPrints ID: 62231
URI: https://eprints.soton.ac.uk/id/eprint/62231
ISSN: 0333-1024
PURE UUID: 8c2b44e7-7a97-4401-a2bd-d1d403f80bcc

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Date deposited: 11 Sep 2008
Last modified: 13 Mar 2019 20:27

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Contributors

Author: A.R. Artemenko
Author: A.L. Kurenkov
Author: E.G. Filatova
Author: S.S. Nikitin
Author: H. Kaube
Author: Z. Katsarava

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