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Minimising metabolic and cardiovascular risk in schizophrenia: diabetes, obesity and dyslipidaemia

Barnett, A.H., Mackin, P., Chaudhry, I., Farooqi, A., Gadsby, R., Heald, A., Hill, J., Millar, H., Peveler, R., Rees, A., Singh, V., Taylor, D., Vora, J. and Jones, P.B. (2007) Minimising metabolic and cardiovascular risk in schizophrenia: diabetes, obesity and dyslipidaemia Journal of Psychopharmacology, 21, (4), pp. 357-373. (doi:10.1177/0269881107075509).

Record type: Article


People with schizophrenia are at greater risk of obesity, Type 2 diabetes, dyslipidaemia and hypertension than the general population. This results in an increased incidence of cardiovascular disease (CVD) and reduced life expectancy, over and above that imposed by their mental illness through suicide. Several levels of evidence from data linkage analyses to clinical trials demonstrate that treatment-related metabolic disturbances are commonplace in this patient group, and that the use of certain second-generation antipsychotics may compound the risk of developing the metabolic syndrome and CVD. In addition, smoking, poor diet, reduced physical activity and alcohol or drug abuse are prevalent in people with schizophrenia and contribute to the overall CVD risk. Management and minimization of metaboLic risk factors are pertinent when providing optimal care to patients with schizophrenia. This review recommends a framework for the assessment, monitoring and management of patients with schizophrenia in the UK clinical setting.

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Published date: 2007
Keywords: antipsychotic, cardiovascular disease, diabetes, dyslipidaemia, hypertension, metabolic syndrome, obesity, schizophrenia


Local EPrints ID: 62310
ISSN: 0269-8811
PURE UUID: d1dcd2ae-6f84-4b67-874e-554786e5f81c
ORCID for R. Peveler: ORCID iD

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Date deposited: 06 Apr 2009
Last modified: 17 Jul 2017 14:20

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Author: A.H. Barnett
Author: P. Mackin
Author: I. Chaudhry
Author: A. Farooqi
Author: R. Gadsby
Author: A. Heald
Author: J. Hill
Author: H. Millar
Author: R. Peveler ORCID iD
Author: A. Rees
Author: V. Singh
Author: D. Taylor
Author: J. Vora
Author: P.B. Jones

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