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Effects of venlafaxine extended release on resilience in posttraumatic stress disorder: an item analysis of the Connor-Davidson Resilience Scale

Effects of venlafaxine extended release on resilience in posttraumatic stress disorder: an item analysis of the Connor-Davidson Resilience Scale
Effects of venlafaxine extended release on resilience in posttraumatic stress disorder: an item analysis of the Connor-Davidson Resilience Scale
The aim was to evaluate the efficacy of venlafaxine extended release (ER) on characteristics of resilience, measured by the Connor-Davidson Resilience Scale, in patients with posttraumatic stress disorder (PTSD). Data were evaluated from a randomized, 6-month, international, multicenter study of adult outpatients with a primary diagnosis of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition PTSD for ?6 months, and 17-item Clinician-Administered PTSD Scale score ?60. Patients were assigned randomly to treatment with flexible-dose venlafaxine ER (37.5-300 mg/day) or placebo. Changes from baseline scores and effect sizes of response to treatment with venlafaxine ER compared with placebo were computed for each item, as well as for the newly developed 2-item and 10-item subscales. Effect sizes across items ranged from 0.41 (moderate) to 0.08 (very weak). The effect size for the Resilience Scale-2 (2-item subscale) was 0.32, which was comparable to the effect sizes of 0.35 for the 25-item full scale and 0.34 for the 10-item subscale. Venlafaxine ER improved resilience on individual Connor-Davidson Resilience Scale items that reflect four factors (hardiness, persistence/tenacity, social support, and faith in a benevolent or meaningful world), to varying degrees in patients with PTSD. The findings suggest that assessment of treatment response might be enhanced by routine evaluation of resilience.
analysis, venlafaxine
0268-1315
299-303
Davidson, Jonathan
3ee9aa6d-9112-4e56-950a-74869aebfb24
Baldwin, David S.
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Stein, Dan J.
07cf0cbd-837d-49ac-aceb-1c393a2f3e00
Pedersen, Ron
bb3776f0-8051-498e-96b3-940642e3ba5b
Ahmed, Saeed
0984c12f-c4f6-46c2-bbe3-b3c45eef17c6
Musnung, Jeff
2a422984-54bf-46bd-9126-7bed928fb77e
Benattia, Isma
3d7c77c0-02af-4983-80c4-9086f3c6aac7
Rothbaum, Barbara O.
d34b0e10-6c38-4199-8b20-62f792f6d020
Davidson, Jonathan
3ee9aa6d-9112-4e56-950a-74869aebfb24
Baldwin, David S.
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Stein, Dan J.
07cf0cbd-837d-49ac-aceb-1c393a2f3e00
Pedersen, Ron
bb3776f0-8051-498e-96b3-940642e3ba5b
Ahmed, Saeed
0984c12f-c4f6-46c2-bbe3-b3c45eef17c6
Musnung, Jeff
2a422984-54bf-46bd-9126-7bed928fb77e
Benattia, Isma
3d7c77c0-02af-4983-80c4-9086f3c6aac7
Rothbaum, Barbara O.
d34b0e10-6c38-4199-8b20-62f792f6d020

Davidson, Jonathan, Baldwin, David S., Stein, Dan J., Pedersen, Ron, Ahmed, Saeed, Musnung, Jeff, Benattia, Isma and Rothbaum, Barbara O. (2008) Effects of venlafaxine extended release on resilience in posttraumatic stress disorder: an item analysis of the Connor-Davidson Resilience Scale. International Clinical Psychopharmacology, 23 (5), 299-303. (doi:10.1097/YIC.0b013e32830c202d).

Record type: Article

Abstract

The aim was to evaluate the efficacy of venlafaxine extended release (ER) on characteristics of resilience, measured by the Connor-Davidson Resilience Scale, in patients with posttraumatic stress disorder (PTSD). Data were evaluated from a randomized, 6-month, international, multicenter study of adult outpatients with a primary diagnosis of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition PTSD for ?6 months, and 17-item Clinician-Administered PTSD Scale score ?60. Patients were assigned randomly to treatment with flexible-dose venlafaxine ER (37.5-300 mg/day) or placebo. Changes from baseline scores and effect sizes of response to treatment with venlafaxine ER compared with placebo were computed for each item, as well as for the newly developed 2-item and 10-item subscales. Effect sizes across items ranged from 0.41 (moderate) to 0.08 (very weak). The effect size for the Resilience Scale-2 (2-item subscale) was 0.32, which was comparable to the effect sizes of 0.35 for the 25-item full scale and 0.34 for the 10-item subscale. Venlafaxine ER improved resilience on individual Connor-Davidson Resilience Scale items that reflect four factors (hardiness, persistence/tenacity, social support, and faith in a benevolent or meaningful world), to varying degrees in patients with PTSD. The findings suggest that assessment of treatment response might be enhanced by routine evaluation of resilience.

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More information

Published date: September 2008
Keywords: analysis, venlafaxine

Identifiers

Local EPrints ID: 62359
URI: http://eprints.soton.ac.uk/id/eprint/62359
ISSN: 0268-1315
PURE UUID: c3af88c6-381d-4f82-90ce-2113bdc64eb5
ORCID for David S. Baldwin: ORCID iD orcid.org/0000-0003-3343-0907

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Date deposited: 21 Apr 2009
Last modified: 16 Mar 2024 02:49

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Contributors

Author: Jonathan Davidson
Author: Dan J. Stein
Author: Ron Pedersen
Author: Saeed Ahmed
Author: Jeff Musnung
Author: Isma Benattia
Author: Barbara O. Rothbaum

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