Langerhans cell histiocytosis of the optic chiasm
Langerhans cell histiocytosis of the optic chiasm
Langerhans cell histiocytosis (LCH) is a rare disease with clonal proliferation of dendritic histiocytes forming a pseudotumoral growth. LCH occurs most frequently in infancy or early childhood. It can present either as a localized self-limiting form or as a diffuse form with multisystem involvement. Herein an unusual case of LCH involving the optic chiasm is presented. To the authors' knowledge, this is the first reported case of LCH presenting with visual disturbance. The clinical, radiological and histopathological findings are discussed.
visual pathway, eye, disturbance, langerhans cell histiocytosis, involvement, growth, central-nervous-system, disease, magnetic resonance imaging, optic chiasm, proliferation, hypothalamus, immunohistochemistry, mr, childhood
66-68
Gangwani, V.
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Walker, M.
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El-Defrawy, H.
cfd813ce-5879-40b6-95a9-2c40332aa431
Nicoll, J.A.R.
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Reck, A.
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Pathmanathan, T.
80ff32e1-7726-4a93-8bdf-33364d542708
2007
Gangwani, V.
8f7a2bcf-daa1-4bd3-9dc0-095112531458
Walker, M.
55b11dc5-60f7-4a90-940a-e89c785c7b93
El-Defrawy, H.
cfd813ce-5879-40b6-95a9-2c40332aa431
Nicoll, J.A.R.
88c0685f-000e-4eb7-8f72-f36b4985e8ed
Reck, A.
6ab3774b-d885-4bb0-9de5-1f129f652722
Pathmanathan, T.
80ff32e1-7726-4a93-8bdf-33364d542708
Gangwani, V., Walker, M., El-Defrawy, H., Nicoll, J.A.R., Reck, A. and Pathmanathan, T.
(2007)
Langerhans cell histiocytosis of the optic chiasm.
Clinical & Experimental Ophthalmology, 35 (1), .
(doi:10.1111/j.1442-9071.2007.01418.x).
Abstract
Langerhans cell histiocytosis (LCH) is a rare disease with clonal proliferation of dendritic histiocytes forming a pseudotumoral growth. LCH occurs most frequently in infancy or early childhood. It can present either as a localized self-limiting form or as a diffuse form with multisystem involvement. Herein an unusual case of LCH involving the optic chiasm is presented. To the authors' knowledge, this is the first reported case of LCH presenting with visual disturbance. The clinical, radiological and histopathological findings are discussed.
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Published date: 2007
Keywords:
visual pathway, eye, disturbance, langerhans cell histiocytosis, involvement, growth, central-nervous-system, disease, magnetic resonance imaging, optic chiasm, proliferation, hypothalamus, immunohistochemistry, mr, childhood
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Local EPrints ID: 62375
URI: http://eprints.soton.ac.uk/id/eprint/62375
ISSN: 1442-6404
PURE UUID: 810b3486-2877-49b6-b3b2-0393223776a2
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Date deposited: 12 Sep 2008
Last modified: 16 Mar 2024 03:26
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Contributors
Author:
V. Gangwani
Author:
M. Walker
Author:
H. El-Defrawy
Author:
A. Reck
Author:
T. Pathmanathan
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