Posterior cingulate neurometabolite profiles and clinical phenotype in frontotemporal dementia
Posterior cingulate neurometabolite profiles and clinical phenotype in frontotemporal dementia
Proton magnetic resonance spectroscopy was used to compare metabolite levels from a posterior cingulate voxel in a group of patients with 2 syndromic subtypes of frontotemporal dementia (n = 10) and an age and education-matched group with Alzheimer disease (n = 10). Overall, frontotemporal dementia was indistinguishable from Alzheimer disease, though differences in N-acetylaspartate emerged between patients with the SD and progressive nonfluent aphasia subtypes, attributable to 2 atypical results among the latter. Such values may index cases with atrophy in posterior cortical regions presenting with progressive nonfluent aphasia
corticobasal degeneration, dementia, mild cognitive impairment, magnetic-resonance, ad, frontotemporal lobar degeneration, primary-progressive-aphasia, mr spectroscopy, alzheimers-disease, dysfunction, lobar degeneration, n-acetylaspartate, sd, progressive nonfluent aphasia, magnetic-resonance-spectroscopy, alzheimer disease, disease, hypometabolism
185-189
Garrard, P.
4815434c-b90e-4998-934b-794c741eea76
Schott, J.M.
17daf131-e500-4f6b-a87d-c983a38e926f
MacManus, D.G.
2a0a1d85-81c8-4c0a-980b-a18901f9c587
Hodges, J.R.
c17af0a9-82e7-4f5a-8a97-d50ec06bbb0a
Fox, N.C.
16f9c9fe-56c7-4ffa-b7cd-6095aba4ecfc
Waldman, A.D.
beb96f7a-905e-43b9-97bf-093ddfeb6716
2006
Garrard, P.
4815434c-b90e-4998-934b-794c741eea76
Schott, J.M.
17daf131-e500-4f6b-a87d-c983a38e926f
MacManus, D.G.
2a0a1d85-81c8-4c0a-980b-a18901f9c587
Hodges, J.R.
c17af0a9-82e7-4f5a-8a97-d50ec06bbb0a
Fox, N.C.
16f9c9fe-56c7-4ffa-b7cd-6095aba4ecfc
Waldman, A.D.
beb96f7a-905e-43b9-97bf-093ddfeb6716
Garrard, P., Schott, J.M., MacManus, D.G., Hodges, J.R., Fox, N.C. and Waldman, A.D.
(2006)
Posterior cingulate neurometabolite profiles and clinical phenotype in frontotemporal dementia.
Cognitive and Behavioral Neurology, 19 (4), .
Abstract
Proton magnetic resonance spectroscopy was used to compare metabolite levels from a posterior cingulate voxel in a group of patients with 2 syndromic subtypes of frontotemporal dementia (n = 10) and an age and education-matched group with Alzheimer disease (n = 10). Overall, frontotemporal dementia was indistinguishable from Alzheimer disease, though differences in N-acetylaspartate emerged between patients with the SD and progressive nonfluent aphasia subtypes, attributable to 2 atypical results among the latter. Such values may index cases with atrophy in posterior cortical regions presenting with progressive nonfluent aphasia
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Published date: 2006
Keywords:
corticobasal degeneration, dementia, mild cognitive impairment, magnetic-resonance, ad, frontotemporal lobar degeneration, primary-progressive-aphasia, mr spectroscopy, alzheimers-disease, dysfunction, lobar degeneration, n-acetylaspartate, sd, progressive nonfluent aphasia, magnetic-resonance-spectroscopy, alzheimer disease, disease, hypometabolism
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Local EPrints ID: 62383
URI: http://eprints.soton.ac.uk/id/eprint/62383
ISSN: 1543-3633
PURE UUID: eb627c1e-6b34-42af-8504-5e16f35dd815
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Date deposited: 10 Sep 2008
Last modified: 08 Jan 2022 19:06
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Author:
P. Garrard
Author:
J.M. Schott
Author:
D.G. MacManus
Author:
J.R. Hodges
Author:
N.C. Fox
Author:
A.D. Waldman
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