Neuropeptides and seizure-induced neurogenesis
Neuropeptides and seizure-induced neurogenesis
We have shown that neuropeptide Y (NPY) regulates neurogenesis in the normal dentate gyrus (DG) via Y1 receptors (Howell et al., 2003, 2005). This regulation may be relevant to epilepsy, because seizures increase both NPY expression and precursor cell proliferation in the DG. Therefore, the effects of NPY on DG precursors were evaluated in normal conditions and after status epilepticus. In addition, potentially distinct NPY responsive precursors were identified, and an analysis performed not only of the DG, but also the caudal subventricular zone (cSVZ) and subcallosal zone (SCZ) where seizures modulate glial precursors. We show a proliferative effect of NPY on multipotent nestin cells expressing the stem cell marker Lewis-X from both the DG and the cSVZ/SCZ in-vitro. We confirm an effect on proliferation in the cSVZ/SCZ of Y1 receptor -/- mice and demonstrate a significant reduction in basal and seizure-induced proliferation in the DG of NPY-/- mice.
Our results show that NPY is a modulator of seizure induced neurogenesis and gliogenesis in a hippocampal region specific manner.
neurogenesis, seizure-induced neurogenesis
36
Gray, W.
d5de3cb8-8bc2-44b7-be8c-ded02317dfc6
23 October 2007
Gray, W.
d5de3cb8-8bc2-44b7-be8c-ded02317dfc6
Gray, W.
(2007)
Neuropeptides and seizure-induced neurogenesis.
[in special issue: 27th International Epilepsy Congress Proceedings]
Epilepsia, 48 Issue s7, .
(doi:10.1111/j.1528-1167.2006.01370_5.x).
Abstract
We have shown that neuropeptide Y (NPY) regulates neurogenesis in the normal dentate gyrus (DG) via Y1 receptors (Howell et al., 2003, 2005). This regulation may be relevant to epilepsy, because seizures increase both NPY expression and precursor cell proliferation in the DG. Therefore, the effects of NPY on DG precursors were evaluated in normal conditions and after status epilepticus. In addition, potentially distinct NPY responsive precursors were identified, and an analysis performed not only of the DG, but also the caudal subventricular zone (cSVZ) and subcallosal zone (SCZ) where seizures modulate glial precursors. We show a proliferative effect of NPY on multipotent nestin cells expressing the stem cell marker Lewis-X from both the DG and the cSVZ/SCZ in-vitro. We confirm an effect on proliferation in the cSVZ/SCZ of Y1 receptor -/- mice and demonstrate a significant reduction in basal and seizure-induced proliferation in the DG of NPY-/- mice.
Our results show that NPY is a modulator of seizure induced neurogenesis and gliogenesis in a hippocampal region specific manner.
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Published date: 23 October 2007
Keywords:
neurogenesis, seizure-induced neurogenesis
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Local EPrints ID: 62392
URI: http://eprints.soton.ac.uk/id/eprint/62392
ISSN: 0013-9580
PURE UUID: 09018bf1-7d33-42a7-be18-b05737eba83c
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Date deposited: 01 Sep 2008
Last modified: 15 Mar 2024 11:30
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Author:
W. Gray
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