Neuropeptide Y signalling on hippocampal stem cells in health and disease
Neuropeptide Y signalling on hippocampal stem cells in health and disease
Neuropeptides are emerging as key components in the hippocampal neurogenic niche in health and disease, regulating many aspects of neurogenesis and the synaptic integration of newly generated neurons. This review focuses on the role of neuropeptide Y in the control of stem/precursor cells in the postnatal and adult hippocampus. It is likely that neuropeptide Y releasing interneurons are key sensors of neural activity, modulating neurogenesis appropriately. This is likely to be a fruitful area of research for extending our understanding of the control of stem cells in the normal and diseased brain.
NPY, stem cell, hippocampus, neurogenesis, interneuron, learning and memory, mood
52-62
Gray, William P.
f34a0e23-3cba-4b0a-8676-a1b2c3e4c095
June 2008
Gray, William P.
f34a0e23-3cba-4b0a-8676-a1b2c3e4c095
Gray, William P.
(2008)
Neuropeptide Y signalling on hippocampal stem cells in health and disease.
Molecular and Cellular Endocrinology, 288 (1-2), .
(doi:10.1016/j.mce.2008.02.021).
Abstract
Neuropeptides are emerging as key components in the hippocampal neurogenic niche in health and disease, regulating many aspects of neurogenesis and the synaptic integration of newly generated neurons. This review focuses on the role of neuropeptide Y in the control of stem/precursor cells in the postnatal and adult hippocampus. It is likely that neuropeptide Y releasing interneurons are key sensors of neural activity, modulating neurogenesis appropriately. This is likely to be a fruitful area of research for extending our understanding of the control of stem cells in the normal and diseased brain.
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Published date: June 2008
Keywords:
NPY, stem cell, hippocampus, neurogenesis, interneuron, learning and memory, mood
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Local EPrints ID: 62393
URI: http://eprints.soton.ac.uk/id/eprint/62393
PURE UUID: 45ae87cd-28fe-4628-8476-d1f1faa2aff7
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Date deposited: 10 Feb 2009
Last modified: 15 Mar 2024 11:30
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Author:
William P. Gray
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