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Association between antipsychotic drugs and diabetes

Holt, Richard I. and Peveler, Robert C. (2006) Association between antipsychotic drugs and diabetes Diabetes, Obesity and Metabolism, 8, (2), pp. 125-135. (doi:10.1111/j.1463-1326.2005.00495.x).

Record type: Article


The link between atypical antipsychotic drugs and the development of diabetes has been hotly debated in the literature. In this review, we attempt to classify the various types of data published and presented in a hierarchical basis. Case reports and retrospective pharmacoepidemiological studies suggest that both conventional and atypical antipsychotic medications are associated with an increased risk of glucose abnormalities or diabetes. Prospective data examining the relationship between atypical antipsychotic drugs and diabetes began to emerge in 2003 and are much less conclusive. Estimates of the attributable risk associated with atypical antipsychotic drugs are low. The few studies that have included a placebo group suggest that we cannot necessarily blame antipsychotic medication when diabetes develops in an individual with schizophrenia.

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Published date: 25 April 2006
Keywords: atypical antipsychotic drugs, diabetes, insulin resistance, schizophrenia


Local EPrints ID: 62410
ISSN: 1462-8902
PURE UUID: 55ba8ac0-d1e0-4432-bbbc-3dedbe6ec8f5
ORCID for Richard I. Holt: ORCID iD
ORCID for Robert C. Peveler: ORCID iD

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Date deposited: 12 Sep 2008
Last modified: 17 Jul 2017 14:20

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