Limitations of the HMPAO SPECT appearances of occipital lobe perfusion in the differential diagnosis of dementia with Lewy bodies
Limitations of the HMPAO SPECT appearances of occipital lobe perfusion in the differential diagnosis of dementia with Lewy bodies
Objective To assess the utility of the appearances of occipital lobe perfusion on HMPAO SPECT in the diagnosis of dementia with Lewy bodies (DLB) using the I-123-FP-CIT findings as the diagnostic 'gold standard'. Methods Eighty-four consecutive patients underwent both HMPAO SPECT and I-123-FP-CIT as part of their routine investigations for suspected DLB. Results Thirty-nine of the 84 FP-CIT scans were abnormal indicating a prevalence of 44% of patients with DLB in this series. In those patients classified as DLB, 28% of HMPAO SPECT scans demonstrated occipital hypoperfusion. In those patients with a dementia other than DLB 31% of patients demonstrated occipital hypoperfusion (P=0.8). Conclusion Occipital lobe hypoperfusion as demonstrated by HMPAO SPECT in patients with suspected Lewy body dementia does not appear to be able to either rule in, or rule out, the diagnosis of DLB
cerebral glucose-metabolism, sensitivity, lewy body dementia, alzheimers-disease, dlb, hmpao, atrophy, ad, validity, dementia with lewy bodies, lewy bodies, fp-cit, parkinsons-disease, spect, prevalence, body dementia, dementia, differential-diagnosis, clinical-criteria, blood-flow
451-456
Kemp, P.M.
c982082a-81d9-404a-b2e6-f2eb19cd1163
Hoffmann, S.A.
1f674c33-d570-4303-a5ca-6193721838ee
Tossici-Bolt, L.
5bb6c0b3-3ba7-4ffc-9922-8f9cdb9f5829
Fleming, J.S.
bf089a52-bc49-402a-9129-0dfecf452936
Holmes, C.
ada5abf3-8459-4cf7-be40-3f4e9391cc96
2007
Kemp, P.M.
c982082a-81d9-404a-b2e6-f2eb19cd1163
Hoffmann, S.A.
1f674c33-d570-4303-a5ca-6193721838ee
Tossici-Bolt, L.
5bb6c0b3-3ba7-4ffc-9922-8f9cdb9f5829
Fleming, J.S.
bf089a52-bc49-402a-9129-0dfecf452936
Holmes, C.
ada5abf3-8459-4cf7-be40-3f4e9391cc96
Kemp, P.M., Hoffmann, S.A., Tossici-Bolt, L., Fleming, J.S. and Holmes, C.
(2007)
Limitations of the HMPAO SPECT appearances of occipital lobe perfusion in the differential diagnosis of dementia with Lewy bodies.
Nuclear Medicine Communications, 28 (6), .
Abstract
Objective To assess the utility of the appearances of occipital lobe perfusion on HMPAO SPECT in the diagnosis of dementia with Lewy bodies (DLB) using the I-123-FP-CIT findings as the diagnostic 'gold standard'. Methods Eighty-four consecutive patients underwent both HMPAO SPECT and I-123-FP-CIT as part of their routine investigations for suspected DLB. Results Thirty-nine of the 84 FP-CIT scans were abnormal indicating a prevalence of 44% of patients with DLB in this series. In those patients classified as DLB, 28% of HMPAO SPECT scans demonstrated occipital hypoperfusion. In those patients with a dementia other than DLB 31% of patients demonstrated occipital hypoperfusion (P=0.8). Conclusion Occipital lobe hypoperfusion as demonstrated by HMPAO SPECT in patients with suspected Lewy body dementia does not appear to be able to either rule in, or rule out, the diagnosis of DLB
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Published date: 2007
Keywords:
cerebral glucose-metabolism, sensitivity, lewy body dementia, alzheimers-disease, dlb, hmpao, atrophy, ad, validity, dementia with lewy bodies, lewy bodies, fp-cit, parkinsons-disease, spect, prevalence, body dementia, dementia, differential-diagnosis, clinical-criteria, blood-flow
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Local EPrints ID: 62440
URI: http://eprints.soton.ac.uk/id/eprint/62440
ISSN: 0143-3636
PURE UUID: 801b1902-d745-4644-b582-9946046ab909
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Date deposited: 12 Sep 2008
Last modified: 09 Jan 2022 03:00
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Author:
P.M. Kemp
Author:
S.A. Hoffmann
Author:
L. Tossici-Bolt
Author:
J.S. Fleming
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