The University of Southampton
University of Southampton Institutional Repository

Limitations of the HMPAO SPECT appearances of occipital lobe perfusion in the differential diagnosis of dementia with Lewy bodies

Limitations of the HMPAO SPECT appearances of occipital lobe perfusion in the differential diagnosis of dementia with Lewy bodies
Limitations of the HMPAO SPECT appearances of occipital lobe perfusion in the differential diagnosis of dementia with Lewy bodies
Objective To assess the utility of the appearances of occipital lobe perfusion on HMPAO SPECT in the diagnosis of dementia with Lewy bodies (DLB) using the I-123-FP-CIT findings as the diagnostic 'gold standard'. Methods Eighty-four consecutive patients underwent both HMPAO SPECT and I-123-FP-CIT as part of their routine investigations for suspected DLB. Results Thirty-nine of the 84 FP-CIT scans were abnormal indicating a prevalence of 44% of patients with DLB in this series. In those patients classified as DLB, 28% of HMPAO SPECT scans demonstrated occipital hypoperfusion. In those patients with a dementia other than DLB 31% of patients demonstrated occipital hypoperfusion (P=0.8). Conclusion Occipital lobe hypoperfusion as demonstrated by HMPAO SPECT in patients with suspected Lewy body dementia does not appear to be able to either rule in, or rule out, the diagnosis of DLB
cerebral glucose-metabolism, sensitivity, lewy body dementia, alzheimers-disease, dlb, hmpao, atrophy, ad, validity, dementia with lewy bodies, lewy bodies, fp-cit, parkinsons-disease, spect, prevalence, body dementia, dementia, differential-diagnosis, clinical-criteria, blood-flow
0143-3636
451-456
Kemp, P.M.
c982082a-81d9-404a-b2e6-f2eb19cd1163
Hoffmann, S.A.
1f674c33-d570-4303-a5ca-6193721838ee
Tossici-Bolt, L.
5bb6c0b3-3ba7-4ffc-9922-8f9cdb9f5829
Fleming, J.S.
bf089a52-bc49-402a-9129-0dfecf452936
Holmes, C.
ada5abf3-8459-4cf7-be40-3f4e9391cc96
Kemp, P.M.
c982082a-81d9-404a-b2e6-f2eb19cd1163
Hoffmann, S.A.
1f674c33-d570-4303-a5ca-6193721838ee
Tossici-Bolt, L.
5bb6c0b3-3ba7-4ffc-9922-8f9cdb9f5829
Fleming, J.S.
bf089a52-bc49-402a-9129-0dfecf452936
Holmes, C.
ada5abf3-8459-4cf7-be40-3f4e9391cc96

Kemp, P.M., Hoffmann, S.A., Tossici-Bolt, L., Fleming, J.S. and Holmes, C. (2007) Limitations of the HMPAO SPECT appearances of occipital lobe perfusion in the differential diagnosis of dementia with Lewy bodies. Nuclear Medicine Communications, 28 (6), 451-456.

Record type: Article

Abstract

Objective To assess the utility of the appearances of occipital lobe perfusion on HMPAO SPECT in the diagnosis of dementia with Lewy bodies (DLB) using the I-123-FP-CIT findings as the diagnostic 'gold standard'. Methods Eighty-four consecutive patients underwent both HMPAO SPECT and I-123-FP-CIT as part of their routine investigations for suspected DLB. Results Thirty-nine of the 84 FP-CIT scans were abnormal indicating a prevalence of 44% of patients with DLB in this series. In those patients classified as DLB, 28% of HMPAO SPECT scans demonstrated occipital hypoperfusion. In those patients with a dementia other than DLB 31% of patients demonstrated occipital hypoperfusion (P=0.8). Conclusion Occipital lobe hypoperfusion as demonstrated by HMPAO SPECT in patients with suspected Lewy body dementia does not appear to be able to either rule in, or rule out, the diagnosis of DLB

This record has no associated files available for download.

More information

Published date: 2007
Keywords: cerebral glucose-metabolism, sensitivity, lewy body dementia, alzheimers-disease, dlb, hmpao, atrophy, ad, validity, dementia with lewy bodies, lewy bodies, fp-cit, parkinsons-disease, spect, prevalence, body dementia, dementia, differential-diagnosis, clinical-criteria, blood-flow

Identifiers

Local EPrints ID: 62440
URI: http://eprints.soton.ac.uk/id/eprint/62440
ISSN: 0143-3636
PURE UUID: 801b1902-d745-4644-b582-9946046ab909
ORCID for C. Holmes: ORCID iD orcid.org/0000-0003-1999-6912

Catalogue record

Date deposited: 12 Sep 2008
Last modified: 09 Jan 2022 03:00

Export record

Contributors

Author: P.M. Kemp
Author: S.A. Hoffmann
Author: L. Tossici-Bolt
Author: J.S. Fleming
Author: C. Holmes ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×