NPY mediates basal and seizure-induced proliferation in the subcallosal zone
NPY mediates basal and seizure-induced proliferation in the subcallosal zone
Stem cell niches exist around the lateral ventricle and in the subgranular layer of the dentate gyrus, supporting adult neurogenesis. Recently, a third germinal layer, the subcallosal zone has been identified supporting the generation of oligodendrocytes in the adult brain. We have previously described a proliferative role for neuropeptide Yon precursors in the dentate gyrus, caudal subventricular zone and subcallosal zone under basal conditions and in the dentate gyrus after seizures. Here we sought to determine a role for neuropeptide Y in seizure-induced proliferation in the subcallosal niche. Using the chemoconvulsant kainate and neuropeptide Y-/- mice with controls, we show an effect of neuropeptide Y on basal proliferation and demonstrate a significant reduction in seizure-induced proliferation in the subcallosal zone.
hippocampus, rat, increases, npy, survival, susceptibility, adult-rat, stem cell, in vivo, cell-proliferation, epilepsy, neural stem cells, brain, progenitors, kainate, germinal layer, neurogenesis
1005-1008
Laskowski, Alexandra
f06f47d0-8587-4074-91b6-eb59f28572ae
Howell, Owain W.
59b875da-844e-4738-9b3b-b9796cf3b21f
Sosuov, Alexander A.
cdf22bbd-56dc-4705-9c2c-97fc86a5b61f
McKhann, Guy
a29f093b-b4f4-456f-a32c-caccc0a61a3f
Gray, William P.
f34a0e23-3cba-4b0a-8676-a1b2c3e4c095
2 July 2007
Laskowski, Alexandra
f06f47d0-8587-4074-91b6-eb59f28572ae
Howell, Owain W.
59b875da-844e-4738-9b3b-b9796cf3b21f
Sosuov, Alexander A.
cdf22bbd-56dc-4705-9c2c-97fc86a5b61f
McKhann, Guy
a29f093b-b4f4-456f-a32c-caccc0a61a3f
Gray, William P.
f34a0e23-3cba-4b0a-8676-a1b2c3e4c095
Laskowski, Alexandra, Howell, Owain W., Sosuov, Alexander A., McKhann, Guy and Gray, William P.
(2007)
NPY mediates basal and seizure-induced proliferation in the subcallosal zone.
NeuroReport, 18 (10), .
Abstract
Stem cell niches exist around the lateral ventricle and in the subgranular layer of the dentate gyrus, supporting adult neurogenesis. Recently, a third germinal layer, the subcallosal zone has been identified supporting the generation of oligodendrocytes in the adult brain. We have previously described a proliferative role for neuropeptide Yon precursors in the dentate gyrus, caudal subventricular zone and subcallosal zone under basal conditions and in the dentate gyrus after seizures. Here we sought to determine a role for neuropeptide Y in seizure-induced proliferation in the subcallosal niche. Using the chemoconvulsant kainate and neuropeptide Y-/- mice with controls, we show an effect of neuropeptide Y on basal proliferation and demonstrate a significant reduction in seizure-induced proliferation in the subcallosal zone.
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Published date: 2 July 2007
Keywords:
hippocampus, rat, increases, npy, survival, susceptibility, adult-rat, stem cell, in vivo, cell-proliferation, epilepsy, neural stem cells, brain, progenitors, kainate, germinal layer, neurogenesis
Identifiers
Local EPrints ID: 62475
URI: http://eprints.soton.ac.uk/id/eprint/62475
PURE UUID: 0b2c6d84-4905-4277-8e28-0e4a4eb6b88d
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Date deposited: 12 Sep 2008
Last modified: 08 Jan 2022 01:13
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Contributors
Author:
Alexandra Laskowski
Author:
Owain W. Howell
Author:
Alexander A. Sosuov
Author:
Guy McKhann
Author:
William P. Gray
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