Linear and nonlinear changes in the auditory brainstem response of aging humans
Linear and nonlinear changes in the auditory brainstem response of aging humans
Objective: This experiment was designed to characterize the changes in linear and nonlinear temporal interactions in the aging auditory brainstem of humans using maximum length sequence (MLS) stimulation.
Methods: The MLS technique uses a quasi-random sequence of clicks and silences to determine the linear (linear averaging of single responses) and nonlinear (interactions between pairs or triplets of responses) temporal interactions in the auditory brainstem response (ABR). A group of 30 normal hearing females aged between I I and 61 years were tested. They were divided in three groups: young ( 41 years).
Results: The linear component showed a decrease in wave 5 amplitude with age which could also be related to increased thresholds for higher frequencies. The nonlinear component of the MLS-ABR showed significant differences between middle and old groups for wave I and 5 latencies and inter-wave interval (1-5).
Conclusions: The results suggest that the linear and nonlinear components of the MLS-ABR could be more sensitive to changes occurring in the auditory system before any functionally significant changes in hearing status. Significance: The nonlinear components of the auditory brainstem could be used as an investigative tool to assess early changes in the aging auditory brainstem in young middle-aged women.
volterra slices, word recognition, auditory brainstem response, components, human listeners, normal-hearing, maximum-length sequences, evoked-responses, stimulation, females, amplitude-modulated stimuli, gap detection, aging, inferior colliculus, auditory, system, brainstem, hearing, maturation, product otoacoustic emissions, nonlinear temporal interactions, clicks, auditory-system, maximum length sequence, contralateral suppression
772-785
Lavoie, B.A.
8acd6a26-0768-41c6-874b-27c226764692
Mehta, R.
1bf632d1-d058-4861-87ca-ae06a07a938a
Thornton, A.R.D.
c521ce20-d056-4748-af28-e2293f3593d0
2008
Lavoie, B.A.
8acd6a26-0768-41c6-874b-27c226764692
Mehta, R.
1bf632d1-d058-4861-87ca-ae06a07a938a
Thornton, A.R.D.
c521ce20-d056-4748-af28-e2293f3593d0
Lavoie, B.A., Mehta, R. and Thornton, A.R.D.
(2008)
Linear and nonlinear changes in the auditory brainstem response of aging humans.
Clinical Neurophysiology, 119 (4), .
(doi:10.1016/j.clinph.2007.12.004).
Abstract
Objective: This experiment was designed to characterize the changes in linear and nonlinear temporal interactions in the aging auditory brainstem of humans using maximum length sequence (MLS) stimulation.
Methods: The MLS technique uses a quasi-random sequence of clicks and silences to determine the linear (linear averaging of single responses) and nonlinear (interactions between pairs or triplets of responses) temporal interactions in the auditory brainstem response (ABR). A group of 30 normal hearing females aged between I I and 61 years were tested. They were divided in three groups: young ( 41 years).
Results: The linear component showed a decrease in wave 5 amplitude with age which could also be related to increased thresholds for higher frequencies. The nonlinear component of the MLS-ABR showed significant differences between middle and old groups for wave I and 5 latencies and inter-wave interval (1-5).
Conclusions: The results suggest that the linear and nonlinear components of the MLS-ABR could be more sensitive to changes occurring in the auditory system before any functionally significant changes in hearing status. Significance: The nonlinear components of the auditory brainstem could be used as an investigative tool to assess early changes in the aging auditory brainstem in young middle-aged women.
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Published date: 2008
Keywords:
volterra slices, word recognition, auditory brainstem response, components, human listeners, normal-hearing, maximum-length sequences, evoked-responses, stimulation, females, amplitude-modulated stimuli, gap detection, aging, inferior colliculus, auditory, system, brainstem, hearing, maturation, product otoacoustic emissions, nonlinear temporal interactions, clicks, auditory-system, maximum length sequence, contralateral suppression
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Local EPrints ID: 62476
URI: http://eprints.soton.ac.uk/id/eprint/62476
PURE UUID: 5bd3bdb9-4bc2-4cde-913c-37fac3e35336
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Date deposited: 11 Sep 2008
Last modified: 15 Mar 2024 11:30
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Author:
B.A. Lavoie
Author:
R. Mehta
Author:
A.R.D. Thornton
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