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Which antidepressants have demonstrated superior efficacy? A review of the evidence

Which antidepressants have demonstrated superior efficacy? A review of the evidence
Which antidepressants have demonstrated superior efficacy? A review of the evidence
A review of published evidence of superior efficacy of a particular antidepressant in major depressive disorder may assist clinicians in making considered treatment choices. To identify such candidates, an international group of experts met to assess published evidence (identified through searches in Medline and Embase databases and discussions with experts in the field) from randomized, controlled trials and meta-analyses comparing two antidepressants under conditions of fair comparison. Criteria were defined to judge the strength of evidence. Two pivotal studies in moderate-to-severe major depressive disorder that demonstrate superiority on the primary efficacy measure, or alternatively one pivotal study supported by consistent results from meta-analyses, was considered to constitute evidence for definite superiority. Three antidepressants met these criteria: clomipramine, venlafaxine, and escitalopram. Three antidepressants were found to have probable superiority: milnacipran, duloxetine, and mirtazapine. Only escitalopram was found to have definite superiority in the treatment of severe depression; probable superiority was identified for venlafaxine and possible superiority for milnacipran and clomipramine. This review of published data found evidence that only a very few antidepressants are shown to be more effective than others
depressive disorder, venlafaxine, antidepressants, london, research, depression, health, review, antidepressant, psychiatry, comparison, treatment
0268-1315
323-329
Montgomery, S.A.
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Baldwin, D.S.
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Blier, P.
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Fineberg, N.A.
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Kasper, S.
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Lader, M.
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Lam, R.W.
a00b7147-6e47-41e5-9522-463d0e41eb7d
Lepine, J.P.
7cf1c4c1-3af0-4249-be55-490918b50369
Moller, H.J.
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Nutt, D.J.
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Rouillon, F.
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Schatzberg, A.F.
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Thase, M.E.
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Montgomery, S.A.
8b3324f3-c514-4f9d-9c33-6af1824da849
Baldwin, D.S.
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Blier, P.
a2d34528-1494-4c40-b422-9b256f40a10a
Fineberg, N.A.
12811850-d727-409a-85a0-51e620cd270f
Kasper, S.
d5cfec73-0b6a-4955-a152-8ceef1dcaa1d
Lader, M.
24f6301f-080d-452e-be88-7f528a99f3b9
Lam, R.W.
a00b7147-6e47-41e5-9522-463d0e41eb7d
Lepine, J.P.
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Moller, H.J.
33b2e076-fc62-4d7b-8019-af425758ae1d
Nutt, D.J.
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Rouillon, F.
062ba41d-820d-4821-bd4c-4b69bdcb6a7e
Schatzberg, A.F.
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Thase, M.E.
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Montgomery, S.A., Baldwin, D.S., Blier, P., Fineberg, N.A., Kasper, S., Lader, M., Lam, R.W., Lepine, J.P., Moller, H.J., Nutt, D.J., Rouillon, F., Schatzberg, A.F. and Thase, M.E. (2007) Which antidepressants have demonstrated superior efficacy? A review of the evidence. International Clinical Psychopharmacology, 22 (6), 323-329.

Record type: Article

Abstract

A review of published evidence of superior efficacy of a particular antidepressant in major depressive disorder may assist clinicians in making considered treatment choices. To identify such candidates, an international group of experts met to assess published evidence (identified through searches in Medline and Embase databases and discussions with experts in the field) from randomized, controlled trials and meta-analyses comparing two antidepressants under conditions of fair comparison. Criteria were defined to judge the strength of evidence. Two pivotal studies in moderate-to-severe major depressive disorder that demonstrate superiority on the primary efficacy measure, or alternatively one pivotal study supported by consistent results from meta-analyses, was considered to constitute evidence for definite superiority. Three antidepressants met these criteria: clomipramine, venlafaxine, and escitalopram. Three antidepressants were found to have probable superiority: milnacipran, duloxetine, and mirtazapine. Only escitalopram was found to have definite superiority in the treatment of severe depression; probable superiority was identified for venlafaxine and possible superiority for milnacipran and clomipramine. This review of published data found evidence that only a very few antidepressants are shown to be more effective than others

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More information

Published date: 2007
Keywords: depressive disorder, venlafaxine, antidepressants, london, research, depression, health, review, antidepressant, psychiatry, comparison, treatment

Identifiers

Local EPrints ID: 62503
URI: http://eprints.soton.ac.uk/id/eprint/62503
ISSN: 0268-1315
PURE UUID: 4b4c9681-cb30-4845-9818-6809477866ac
ORCID for D.S. Baldwin: ORCID iD orcid.org/0000-0003-3343-0907

Catalogue record

Date deposited: 10 Sep 2008
Last modified: 09 Jan 2022 02:48

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Contributors

Author: S.A. Montgomery
Author: D.S. Baldwin ORCID iD
Author: P. Blier
Author: N.A. Fineberg
Author: S. Kasper
Author: M. Lader
Author: R.W. Lam
Author: J.P. Lepine
Author: H.J. Moller
Author: D.J. Nutt
Author: F. Rouillon
Author: A.F. Schatzberg
Author: M.E. Thase

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