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Befriending patients with medication-resistant schizophrenia: can psychotic symptoms predict treatment response?

Befriending patients with medication-resistant schizophrenia: can psychotic symptoms predict treatment response?
Befriending patients with medication-resistant schizophrenia: can psychotic symptoms predict treatment response?
Objectives. Supportive interventions are used in schizophrenia, but little research has been conducted into whether any baseline variable predicts treatment response. The aim of this study was to establish if baseline delusions or hallucinations are associated with changes in overall symptoms in patients who received a befriending intervention.
Design. The sample consisted of 44 patients with schizophrenia. These patients comprised the befriending arm of a multicentre randomized controlled trial which compared the efficacy of using CBT against befriending as an adjunct to routine care for patients with medication-resistant schizophrenia.
Methods. Scores for auditory hallucinations and delusions relating to persecution or control were entered into two regression models. The dependent variables were change in overall symptoms (1) between baseline and end of the intervention, and (2) between baseline and 9 months post-intervention.
Results. Baseline delusions predicted a good response and auditory hallucinations predicted a poor response at 9 months. Conclusions. Baseline psychotic symptoms strongly predicted outcome in this sample. The finding that hallucinations predicted a poor outcome is consistent with previous research. These results may help to determine which patients would benefit from supportive interventions.
patients, treatment, schizophrenia
1476-0835
97-106
Samarasekera, N.
f0e66d1d-d60e-46ea-a420-bd29f8bd69a0
Kingdon, D.
14cdc422-10b4-4b2d-88ec-24fde5f4329b
Siddle, R.
4dccea5c-bab9-4f97-bedb-7641506c523a
O'Carroll, M.
55fa98c2-b06d-4a7e-a67e-71865930971a
Scott, J.L.
15af6b2e-2639-48b3-943a-a8ba8d0b6fd9
Sensky, T.
9ca2b6d0-57aa-43b4-b3a1-d703332db551
Barnes, T.R.
d1d261e4-fa1a-46d0-b311-47bb6a29ae52
Turkington, D.
a1e362f5-4ff3-4d27-81cb-1c6ddbcbf5b9
Samarasekera, N.
f0e66d1d-d60e-46ea-a420-bd29f8bd69a0
Kingdon, D.
14cdc422-10b4-4b2d-88ec-24fde5f4329b
Siddle, R.
4dccea5c-bab9-4f97-bedb-7641506c523a
O'Carroll, M.
55fa98c2-b06d-4a7e-a67e-71865930971a
Scott, J.L.
15af6b2e-2639-48b3-943a-a8ba8d0b6fd9
Sensky, T.
9ca2b6d0-57aa-43b4-b3a1-d703332db551
Barnes, T.R.
d1d261e4-fa1a-46d0-b311-47bb6a29ae52
Turkington, D.
a1e362f5-4ff3-4d27-81cb-1c6ddbcbf5b9

Samarasekera, N., Kingdon, D., Siddle, R., O'Carroll, M., Scott, J.L., Sensky, T., Barnes, T.R. and Turkington, D. (2007) Befriending patients with medication-resistant schizophrenia: can psychotic symptoms predict treatment response? Psychology and Psychotherapy: Theory, Research and Practice, 80 (1), 97-106. (doi:10.1348/147608306X108998).

Record type: Article

Abstract

Objectives. Supportive interventions are used in schizophrenia, but little research has been conducted into whether any baseline variable predicts treatment response. The aim of this study was to establish if baseline delusions or hallucinations are associated with changes in overall symptoms in patients who received a befriending intervention.
Design. The sample consisted of 44 patients with schizophrenia. These patients comprised the befriending arm of a multicentre randomized controlled trial which compared the efficacy of using CBT against befriending as an adjunct to routine care for patients with medication-resistant schizophrenia.
Methods. Scores for auditory hallucinations and delusions relating to persecution or control were entered into two regression models. The dependent variables were change in overall symptoms (1) between baseline and end of the intervention, and (2) between baseline and 9 months post-intervention.
Results. Baseline delusions predicted a good response and auditory hallucinations predicted a poor response at 9 months. Conclusions. Baseline psychotic symptoms strongly predicted outcome in this sample. The finding that hallucinations predicted a poor outcome is consistent with previous research. These results may help to determine which patients would benefit from supportive interventions.

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More information

Published date: March 2007
Keywords: patients, treatment, schizophrenia

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Local EPrints ID: 62562
URI: http://eprints.soton.ac.uk/id/eprint/62562
ISSN: 1476-0835
PURE UUID: 247e2a5b-a770-4730-92e3-e5e61dc4d5c7

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Date deposited: 12 Sep 2008
Last modified: 15 Mar 2024 11:31

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Contributors

Author: N. Samarasekera
Author: D. Kingdon
Author: R. Siddle
Author: M. O'Carroll
Author: J.L. Scott
Author: T. Sensky
Author: T.R. Barnes
Author: D. Turkington

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