Nimodipine for subarachnoid haemorrhage: the end of the road or better trials?
Nimodipine for subarachnoid haemorrhage: the end of the road or better trials?
Traumatic subarachnoid haemorrhage is a common finding in all degrees of severity of head injury and is an independent predictor of poor outcome. However, to what extent the presence of subarachnoid blood contributes to secondary deterioration or whether this is simply an epiphenomenon of the injury is unclear. In patients with aneurysmal subarachnoid haemorrhage nimodipine is widely used for the prevention and treatment of cerebral vasospasm, a major contributor to morbidity and mortality in this disorder. Although the main effect of nimodipine is thought to be relaxation of the smooth muscle of the cerebral vasculature mediated by its Ca2+ antagonistic action, other mechanisms have been invoked, including possible antioxidant activity
trial
993-994
Sen, Jon
464edd7f-7891-4e3f-a86c-0675fd129828
Belli, Antonio
33707b7b-b004-4245-aead-98a8e1e2b2e2
2006
Sen, Jon
464edd7f-7891-4e3f-a86c-0675fd129828
Belli, Antonio
33707b7b-b004-4245-aead-98a8e1e2b2e2
Sen, Jon and Belli, Antonio
(2006)
Nimodipine for subarachnoid haemorrhage: the end of the road or better trials?
The Lancet Neurology, 5 (12), .
(doi:10.1016/S1474-4422(06)70583-X).
Abstract
Traumatic subarachnoid haemorrhage is a common finding in all degrees of severity of head injury and is an independent predictor of poor outcome. However, to what extent the presence of subarachnoid blood contributes to secondary deterioration or whether this is simply an epiphenomenon of the injury is unclear. In patients with aneurysmal subarachnoid haemorrhage nimodipine is widely used for the prevention and treatment of cerebral vasospasm, a major contributor to morbidity and mortality in this disorder. Although the main effect of nimodipine is thought to be relaxation of the smooth muscle of the cerebral vasculature mediated by its Ca2+ antagonistic action, other mechanisms have been invoked, including possible antioxidant activity
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Published date: 2006
Keywords:
trial
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Local EPrints ID: 62576
URI: http://eprints.soton.ac.uk/id/eprint/62576
ISSN: 1474-4422
PURE UUID: 97a88453-6e27-4fb7-9784-f482a57ed641
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Date deposited: 05 Sep 2008
Last modified: 15 Mar 2024 11:31
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Author:
Jon Sen
Author:
Antonio Belli
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