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Efficacy of pregabalin in depressive symptoms associated with generalized anxiety disorder: a pooled analysis of 6 studies

Stein, Dan J., Baldwin, David S., Baldinetti, Francesca and Mandel, Francine (2008) Efficacy of pregabalin in depressive symptoms associated with generalized anxiety disorder: a pooled analysis of 6 studies European Neuropsychopharmacology, 18, (6), pp. 422-430. (doi:10.1016/j.euroneuro.2008.01.004).

Record type: Article


Epidemiological evidence supports comorbidity of generalized anxiety disorder (GAD) and major depressive disorder (MDD) or dysthymia, and its association with significant disability. As pregabatin, a new alpha(2)-delta anxiolytic treatment for GAD, unlike most other licensed treatments for GAD has not undergone investigation in patients with MDD, we examined its efficacy in depressive symptoms associated with GAD, through a post-hoc analysis of the existing clinical trial database. The results provide consistent evidence that in patients with GAD pregabalin reduced associated symptoms of depression. This was seen in the 150 mg/day, 300-450 mg/day and 600 mg/day dosing groups. Even in subjects with more prominent depressive symptoms, pregabalin remained effective for both sub-syndromal depression and GAD symptoms, with pregabatin 300-450 mg/day demonstrating the most beneficial response. In conclusion, pregabalin, an alternative treatment option for GAD with a novel mechanism of action, also demonstrated efficacy in treating depressive symptoms typically encountered in GAD patients.

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Published date: June 2008
Keywords: efficacy, generalized anxiety disorder, major depression, diabetic peripheral neuropathy, double-blind, postherpetic neuralgia, rat neocortical slices, gad, protein-kinase-c, comorbid depressive symptoms, pregabalin, dsm-iv, primary-care, major depressive disorder, venlafaxine extended-release, placebo-controlled trial


Local EPrints ID: 62612
ISSN: 0924-977X
PURE UUID: 4af54390-05fa-4ed6-8fb1-41fb42e29982

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Date deposited: 04 Nov 2008
Last modified: 17 Jul 2017 14:20

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Author: Dan J. Stein
Author: Francesca Baldinetti
Author: Francine Mandel

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